{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:34Z","timestamp":1778498494823,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aggressive digital papillary adenocarcinoma (<jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content>) is a rare adenocarcinoma of the sweat glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We wish to report the treatment of two cases of <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> with Mohs micrographic surgery and review the presentation, management, and prognosis of this rare malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Cases of <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> were identified from recent surgery logs. Demographic, tumor, and treatment characteristics were extracted. A PubMed database search for English language full\u2010text articles of aggressive digital papillary adenocarcinoma was performed, and relevant articles were summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two cases of <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> were identified. A 53\u2010year\u2010old man presented with <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> on his right third fingernail, and a 65\u2010year\u2010old man presented with <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> on his right thumb. Both patients underwent Mohs micrographic surgery and negative sentinel lymph node biopsy, remaining recurrence free at 34 and 9 months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> frequently presents as a solitary mass on the digit. Treatment of <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> with local excision or amputation has historically been fraught with high recurrence rates. Regional lymph node spread and distant metastasis have been reported. Mohs micrographic surgery may be an alternative treatment for <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mohs micrographic surgery is a viable option for <jats:styled-content style=\"fixed-case\">ADPA<\/jats:styled-content> and warrants further exploration. Long\u2010term follow\u2010up is important, and additional studies will need to identify the role of sentinel lymph node biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13712","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T11:26:36Z","timestamp":1503314796000},"page":"1061-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Aggressive digital papillary adenocarcinoma: treatment with Mohs micrographic surgery and an update of the literature"],"prefix":"10.1111","volume":"56","author":[{"given":"Rebecca W.","family":"Knackstedt","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Cleveland Clinic Foundation Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Knackstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cleveland Clinic Foundation Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa B.","family":"Findley","sequence":"additional","affiliation":[{"name":"Dermatology Professionals, Inc. 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