{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:33:44Z","timestamp":1791398024100,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Statutory Research","award":["503\/3-066-01\/503-31-001"],"award-info":[{"award-number":["503\/3-066-01\/503-31-001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The epidermis is an epidermal barrier which accumulates lipid substances and participates in skin moisturizing. An evaluation of the epidermal barrier efficiency can be made, among others, by the measurement of the following values: the lipid coat, the transepidermal water loss (TEWL) index, and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>The study involved 50 Caucasian, healthy women aged 19\u201335 years (mean 20.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Measurements were made using Courage &amp; Khazaka Multi Probe Adapter <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content> 580: Tewameter <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> 300, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010Meter <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> 905, Sebumeter <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> 815. The areas of measurements included forehead, nose, left cheek, right cheek, chin, and thigh.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the T\u2010zone, the lipid coat was in the range between 0 and 270 \u03bcg\/cm<jats:sup>2<\/jats:sup> (mean 128 \u03bcg\/cm<jats:sup>2<\/jats:sup>), <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> between 1 and 55 g\/m<jats:sup>2<\/jats:sup>\/h (mean 11.1 g\/m<jats:sup>2<\/jats:sup>\/h), and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 4.0\u20135.6 (mean 5.39). Lower values of the lipid coat up to 100 \u03bcg\/cm<jats:sup>2<\/jats:sup> were accompanied by <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> greater than 30 g\/m<jats:sup>2<\/jats:sup>\/h and less acidic <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> of 5.6\u20139.0. In the U\u2010zone the range of lipid coat was up to 200 \u03bcg\/cm<jats:sup>2<\/jats:sup> (mean 65.2 \u03bcg\/cm<jats:sup>2<\/jats:sup>), the skin <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> remained 4.0\u20135.6 (mean 5.47), and TEWL was in the range between 1 and 20 g\/m<jats:sup>2<\/jats:sup>\/h (mean 8.7 g\/m<jats:sup>2<\/jats:sup>\/h). Lower values of the lipid coat up to 100 \u03bcg\/cm<jats:sup>2<\/jats:sup> were accompanied by <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> between 1 and 20 g\/m<jats:sup>2<\/jats:sup>\/h and less acidic <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> of 5.6\u20139.0. High values of the lipid coat between 180 and 200 \u03bcg\/cm<jats:sup>2<\/jats:sup> were connected with <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> of 1\u201315 g\/m<jats:sup>2<\/jats:sup>\/h. On the skin of the thigh, we observed a very thin lipid coat \u2013 35 \u03bcg\/cm<jats:sup>2<\/jats:sup> (mean 5.6 \u03bcg\/cm<jats:sup>2<\/jats:sup>), <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> (mean 5.37), and <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> (mean 8.5 g\/m<jats:sup>2<\/jats:sup>\/h) were considered by us to be within regular limits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the T\u2010zone, a thinner lipid coat resulted in relatively high <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> levels changing toward alkaline. In the U\u2010zone, thinner lipid coat was accompanied by lower <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> changing toward alkaline. We also observed that lower values of lipid coat up to 100 \u03bcg\/cm<jats:sup>2<\/jats:sup> were associated with higher <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> values ranging toward the basic character <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> 5.6\u20139.0).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13726","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T10:53:16Z","timestamp":1504867996000},"page":"1192-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of the relation between lipid coat, transepidermal water loss, and skin <scp>pH<\/scp>"],"prefix":"10.1111","volume":"56","author":[{"given":"Barbara","family":"Algiert\u2010Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Cosmetology and Aesthetic Dermatology Medical University of Lodz Lodz 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