{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:25:30Z","timestamp":1785173130652,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Relapsing polychondritis is an autoimmune multisystemic disease with primary chondral involvement. Its high mortality and morbidity make it a real clinical challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>A 32\u2010year\u2010old woman with a history of relapsing polychondritis, refractory to multiple treatments, with multisystem compromise, imminent risk of death due to severe tracheobronchial damage and difficult ventilatory support, and successful treatment with infliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and evaluation<\/jats:title><jats:p>Several treatments have been described in the literature, such as nonsteroidal anti\u2010inflammatory drugs, corticosteroids, dapsone, azathioprine, cyclosporine, cyclophosphamide, and methotrexate. However, the cases refractory to conventional therapy may lead to chronicity, irreversibility, and death. As a result, a third\u2010line therapy could improve the prognosis of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biological therapy is a good option for disease control and quality of life improvement. In addition, the physician should consider these treatments to avoid the chronicity and risk of death of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13755","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T04:18:34Z","timestamp":1507609114000},"page":"1379-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relapsing polychondritis, an underestimated dermatological urgency: case report and literature review"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9408-0907","authenticated-orcid":false,"given":"Daniel","family":"Cuestas","sequence":"first","affiliation":[{"name":"Dermatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"},{"name":"Dermatology Program El Bosque University Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-5217","authenticated-orcid":false,"given":"Elkin","family":"Pe\u00f1aranda","sequence":"additional","affiliation":[{"name":"Dermatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"},{"name":"Dermatology Program National University of Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-3626","authenticated-orcid":false,"given":"Sergio","family":"Mora","sequence":"additional","affiliation":[{"name":"Rheumatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6360-482X","authenticated-orcid":false,"given":"Carolina","family":"Cortes","sequence":"additional","affiliation":[{"name":"Dermatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"},{"name":"Dermatology Program National University of Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-4200","authenticated-orcid":false,"given":"Ingrid","family":"Galvis","sequence":"additional","affiliation":[{"name":"Rheumatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"},{"name":"Radiology Program La Sabana University Chia Coloumbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-8667","authenticated-orcid":false,"given":"M\u00f3nica","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Dermatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-4320","authenticated-orcid":false,"given":"Oscar","family":"Velasquez","sequence":"additional","affiliation":[{"name":"Dermatology Service Samaritana University Hospital \u2010 ESE Bogot\u00e1 Colombia"},{"name":"Dermatology Program National University of Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200401000-00011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.04.004"},{"key":"e_1_2_7_5_1","first-page":"1","article-title":"Relapsing polychondritis. A study of 19 cases in Colombia. Salud Uninorte","volume":"23","author":"Quintana Duque M.A","year":"2007","journal-title":"Barranquilla (Col.)"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.007"},{"key":"e_1_2_7_7_1","first-page":"93","article-title":"Polychondropathia","volume":"6","author":"Jaksch\u2010Wartenhorst R","year":"1923","journal-title":"Wien Arch J Intern"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196007142630201"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197906000-00009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91439"},{"key":"e_1_2_7_11_1","first-page":"2181","article-title":"Incidence and mortality of relapsing polychondritis in the UK: a population\u2010based cohort study","volume":"54","author":"Hazra N","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10020494"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0226-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.07.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39790"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2328-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.06.005"},{"key":"e_1_2_7_18_1","first-page":"96","article-title":"Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients","volume":"24","author":"Zeuner M","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<238::AID-ART10030>3.0.CO;2-M"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63183-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310303"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2402::AID-ART405>3.0.CO;2-L"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.02.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.07.018"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.03.002"},{"key":"e_1_2_7_27_1","first-page":"1","article-title":"Relapsing Polychondritis: an update on pathogenesis, clinical features, diagnostic tools, and therapeutic perspectives","volume":"18","author":"Vitale A","year":"2015","journal-title":"Curr Rheumatol Rep"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20613"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.32586"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.08.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004496"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-015-2270-x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu147"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198705000-00004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.3.413"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350716"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200105000-00003"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.02.013"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3160-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00135.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.08.006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg280"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701457"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02923.x"},{"key":"e_1_2_7_45_1","first-page":"1413","article-title":"Treatment of relapsing polychondritis with a TNF antagonist","volume":"32","author":"Carter JD","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep224"},{"key":"e_1_2_7_47_1","first-page":"1394","article-title":"Sustained response to infliximab in 2 patients with refractory relapsing polychondritis","volume":"30","author":"Saadoun D","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_7_48_1","first-page":"211","article-title":"Infliximab in relapsing polychondritis","volume":"50","author":"Soares de Barros AP","year":"2010","journal-title":"Rev Bras Rheumatol"},{"key":"e_1_2_7_49_1","first-page":"937e9","article-title":"Biologics in relapsing polychondritis: a case series","volume":"31","author":"Moulis G","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel041"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.02.011"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep436"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken468"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24366"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:59:25Z","timestamp":1695718765000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,9]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/ijd.13755"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13755","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,9]]},"assertion":[{"value":"2017-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}