{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:25:28Z","timestamp":1789586728377,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No ethnic or geographic predisposition to bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) was reported so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate trends in the incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in northern Israel, shedding light on differences between two distinct ethnic populations who inhabit the same region, namely Jews and Arabs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bullous pemphigoid incidence was retrospectively estimated from January 2000\u2013December 2015 in two Israeli regions with a total population of 1.56\u00a0million inhabitants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 287 new\u2010onset <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients (mean age: 77.6\u00a0\u00b1\u00a012.1) were identified. The incidence rate was 11.4 per million inhabitants per year (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 10.2\u201312.9). The crude incidence rate in Jews was 4.8\u2010fold higher than that in Arabs (16.4 vs. 3.4 cases per million per year, respectively [<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]). After adjusting for age, the discrepancy between the two populations diminished (11.7 vs. 8.9 cases per million per year, respectively) but remained statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.032). The incidence increased consistently from 7.6 cases per million per year in the calendar period 2000\u20132005 to 12.6 and 14.3 cases in 2006\u20132010 and 2011\u20132015, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Bullous pemphigoid patients of Arab ancestry presented with the disease significantly earlier than Jews (69.5\u00a0\u00b1\u00a015.3 vs. 78.7\u00a0\u00b1\u00a011.1\u00a0years, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in northern Israel has increased in the last 16\u00a0years and is significantly higher among Jews compared to Arabs. The age of presentation is remarkably different between patients belonging to the two populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13813","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T04:36:41Z","timestamp":1509511001000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ethnic variations in the epidemiology of bullous pemphigoid in Israel"],"prefix":"10.1111","volume":"57","author":[{"given":"Khalaf","family":"Kridin","sequence":"first","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus Haifa Israel"},{"name":"Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113803"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"17784","DOI":"10.1016\/S0021-9258(18)55195-4","article-title":"Human bullous pemphigoid antigen (BPAG1): amino acid sequences deduced from cloned cDNAs predict biologically important peptide segments and protein domains","volume":"266","author":"Sawamura D","year":"1991","journal-title":"J Biol Chem"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116856"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60503-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690130050009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09300.x"},{"issue":"1","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0190-9622(99)70061-7","article-title":"Increased risk of bullous pemphigoid in male and very old patients: a population\u2010based study on incidence","volume":"41","author":"Jung M","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04345.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02292.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06976_supp.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.35"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archderm.1995.01690200097021","article-title":"Incidence of autoimmune subepidermal blistering dermatoses in a region of central Germany","volume":"131","author":"Wever S","year":"1995","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06662.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.301"},{"issue":"09","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"a180","DOI":"10.1136\/bmj.a180","article-title":"Bullous pemphigoid and pemphigus vulgaris\u2013incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan SM","year":"2008","journal-title":"BMJ"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690200097021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8569"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02141.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.07.002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)03007-X"},{"key":"e_1_2_6_22_1","unstructured":"Israeli Central Bureau of Statisticsdata for 2014. 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