{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:27Z","timestamp":1787014347325,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"publisher","award":["13MMH\u2010106\u2010106"],"award-info":[{"award-number":["13MMH\u2010106\u2010106"]}],"id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Epidermolytic acanthoma (\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      ) is an uncommon benign cutaneous lesion. Multiple epidermolytic acanthomas (multiple\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      s) are rarely reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively identified patients diagnosed with multiple\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      s between 2005 and 2017 from our dermatopathology database and analyzed their clinical, pathological, and immunohistochemical features. We also evaluated the association of multiple\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      s with human papillomavirus (HPV) infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, eight patients (average age 51\u00a0years; 3\u00a0:\u00a01 male predominance) with multiple\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      s were found. All patients had lesions on the genitocrural area. The two most common clinical diagnoses were condyloma (5\/8) and soft fibroma (3\/8), which were predominantly skin\u2010colored (5\/8) or whitish (2\/8). The lesions were less than 1\u00a0cm in diameter, and most (6\/8) appeared to have a smooth surface. No molecular evidence suggesting HPV infection was found. Immunohistochemical staining showed low mitotic activity. The lesions were removed in one of two patients via cryotherapy, and one patient was treated with electrocauterization. The other five patients were followed without treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The genital area was the most common location for multiple\n                      <jats:styled-content style=\"fixed-case\">EA<\/jats:styled-content>\n                      s, which was commonly misdiagnosed clinically as condyloma. Patients presenting with uniformly small\u2010sized, skin\u2010colored to whitish, smooth papular lesions in the genitalia should be carefully evaluated. The specific pathological features of epidermolytic hyperkeratosis are diagnostic, and the lesions can be observed without aggressive treatment after confirmed diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.13818","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:36:43Z","timestamp":1509496603000},"page":"28-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases"],"prefix":"10.1111","volume":"57","author":[{"given":"Tsung\u2010Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Mackay Memorial Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mackay Memorial Hospital Taipei Taiwan"},{"name":"Department of Medicine Mackay Medical College New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2340\/0001555553393402","article-title":"Disseminated epidermolytic acanthoma. 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