{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:26:21Z","timestamp":1748553981522,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Georgia Dermatopathology Associates"},{"name":"Mineros SA"},{"name":"Hospital Nuestra Se\u00f1ora del Carmen"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre\u2010<jats:styled-content style=\"fixed-case\">EPF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here we aimed to investigate disease autoreactivity to vessels in all body organs\/systems. We compared 57 patients and 57 controls from the endemic area, matched by demographics, age, sex, and work activity. We performed immunofluorescence, immunohistochemistry, confocal microscopy, immunoblotting, indirect immune electron microscopy studies, and autometallographic studies. We performed ultrasonography on large patient arteries, investigating for vascular anomalies. In addition, we reviewed autopsies on seven patients who died affected by El Bagre\u2010<jats:styled-content style=\"fixed-case\">EPF<\/jats:styled-content>. We immunoadsorbed any positive vessel immunofluorescence with desmoglein (Dsg1), investigating for new autoantigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 57\/57 patients affected by El Bagre\u2010<jats:styled-content style=\"fixed-case\">EPF<\/jats:styled-content> displayed autoantibodies to vessels in all the organs\/systems of the body via all methods (<jats:italic>P<\/jats:italic> &lt; 0.01). The autoreactivity was polyclonal, and the patient's antibodies colocalized with commercial antibodies to desmoplakins I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, p0071, <jats:styled-content style=\"fixed-case\">ARVCF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">MYZAP<\/jats:styled-content> (all from Progen Biotechnik, Germany; <jats:italic>P<\/jats:italic> &lt; 0.01; all present at cell junctions). Immunoadsorption with Dsg1 on positive vessel immunofluorescence showed that the immune response against the vessels was directed against non\u2010Dsg1 antigen(s). Autometallographic studies showed deposits of metals and metalloids in vessel cell junctions and in erythrocytes of 85% of patients (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immune response to these vascular antigens is likely altering endothelial cells and vessel shapes, thus disturbing hemodynamic flow. The flow alterations likely lead to inflammation and may play a role in the atherogenesis often seen in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13827","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T09:24:00Z","timestamp":1511169840000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Autoantibodies to full body vascular cell junctions colocalize with MYZAP, ARVCF, desmoplakins I and II and p0071 in endemic pemphigus in Colombia, South America"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-4133","authenticated-orcid":false,"given":"Ana M.","family":"Abreu Velez","sequence":"first","affiliation":[{"name":"Georgia Dermatopathology Associates Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yi","sequence":"additional","affiliation":[{"name":"Robert P. Apkarian Integrated Electron Microscopy Core Emory University Medical Center Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Warfvinge","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Howard","sequence":"additional","affiliation":[{"name":"Georgia Dermatopathology Associates Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"51","article-title":"Endemic pemphigus foliaceus over a century: part 1","volume":"2","author":"Abreu\u2010Velez AM","year":"2010","journal-title":"N Am J Med Sci"},{"key":"e_1_2_7_3_1","first-page":"574","article-title":"Similarities and differences between Brazilian wild fire and pemphigus foliaceus 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