{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:20:04Z","timestamp":1773814804713,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immune checkpoint antibody blockade is an emerging therapeutic option for treating certain cancers including melanoma. This therapy is associated with dermatologic and systemic toxicities, some of which are more severe than others and may require withholding therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case reports<\/jats:title><jats:p>We report two patients with melanocytic nevi that regressed with pembrolizumab therapy. The first patient had stage <jats:styled-content style=\"fixed-case\">IV <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> K601E\/L584F<\/jats:italic> mutant melanoma that developed a regressed melanocytic nevus while being treated with pembrolizumab. The second patient had stage <jats:styled-content style=\"fixed-case\">III <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content> V600R<\/jats:italic> mutant melanoma that was treated with pembrolizumab and dabrafenib, and also developed a regressed melanocytic nevus. Both patients had good response to therapy and stable disease at 8 and 12\u00a0months of treatment, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regressed melanocytic nevi were observed in both patients treated with pembrolizumab for advance\u2010stage melanoma. Immunohistochemical analysis of a regressed melanocytic nevus was associated with an inflammatory infiltrate rich in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ T cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163+, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>11c+ histiocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regressed melanocytic nevi are an emerging dermatologic effect from pembrolizumab therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13833","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T09:24:28Z","timestamp":1511169868000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Regressed melanocytic nevi secondary to pembrolizumab therapy: an emerging melanocytic dermatologic effect from immune checkpoint antibody 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