{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T09:17:32Z","timestamp":1696065452295},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T00:00:00Z","timestamp":1513382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite suffering high ultraviolet radiation levels, few data on malignant melanoma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) in Macaronesia are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational study of cutaneous <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cases diagnosed during a period of 12 years at a tertiary hospital in Canary Islands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 532 patients (female\/male = 1.4) with an average age of 56 years were included; 5% developed more than one <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, and 7% reported family history of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. Phototype <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (43%), dark eyes (41%), and dark hair (41%) predominated. There was a lower frequency of light\u2010colored hair and eyes in those born in the Canary Islands. The most frequent locations of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> were on the back for men (37%) and on the lower extremities for women (35%). Among the infiltrating tumors (83%), the (median) thickness was 1.07 mm (women, 0.90 mm; men, 1.21 mm). Anatomopathological ulceration (<jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content>) and a mitotic rate \u22651 mitosis\/mm<jats:sup>2<\/jats:sup> (<jats:styled-content style=\"fixed-case\">HMR<\/jats:styled-content>) were recorded in 27% of patients. Patients with regional disease constituted 12% of the population. The most common stage was <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (34%). Melanoma\u2010specific survival (<jats:styled-content style=\"fixed-case\">MSSV<\/jats:styled-content>) decreased significantly with thickness, presence of <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HMR<\/jats:styled-content>, and sentinel lymph node disease. These four variables were independent prognostic factors. The five\u2010year <jats:styled-content style=\"fixed-case\">MSSV<\/jats:styled-content> varied between 100% (stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) and 39% (stage <jats:styled-content style=\"fixed-case\">IIIC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The characteristics of the patients were similar to those published in datasets from continental Europe, although the pigmentary features were darker in those originating from Macaronesia. The prognostic parameters described in the 7th edition of the <jats:styled-content style=\"fixed-case\">American Joint Committee on Cancer (AJCC)<\/jats:styled-content> independently predict <jats:styled-content style=\"fixed-case\">MSSV<\/jats:styled-content> in our patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13848","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:20:50Z","timestamp":1513462850000},"page":"193-201","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological characteristics of cutaneous malignant melanoma in patients at a tertiary hospital in Macaronesia. 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