{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:01:54Z","timestamp":1790913714047,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Short\u2010term mucocutaneous adverse effects are well documented with imatinib. However, studies on long\u2010term adverse effects and in the ethnic population are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the long\u2010term mucocutaneous adverse effects of imatinib and factors predicting these adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, consenting adult chronic myeloid leukemia patients on imatinib for more than 250 days were recruited. The details of imatinib treatment were retrieved from hematology clinic records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and thirty\u2010eight patients who were on imatinib for a mean duration of 1820 days were recruited. A mean number of 1.42 \u00b1 0.98 cutaneous adverse effects were seen per patient. Melasma\u2010like pigmentation, periorbital edema, oral lichenoid reaction, cutaneous hypopigmentation, and vesicobullous eruptions were seen in 236 (53.9%), 81 (18.5%), 70 (16%), 42 (9.6%), and 12 (2.7%) patients, respectively. Drug\u2010induced cutaneous eruptions (9.1%) and cutaneous hypopigmentation (9.6%) were seen less frequently. Cutaneous hyperpigmentation was more likely seen in younger patients (<jats:italic>P<\/jats:italic> = 0.001) and females (<jats:italic>P<\/jats:italic> &lt; 0.001). On multivariate analysis, female gender was a significant risk factor for developing cutaneous hyperpigmentation and periorbital edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cutaneous hyperpigmentation and periorbital edema are common long\u2010term adverse effects of imatinib in Indian patients. Female gender is a significant risk factor for the development of both these adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13852","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T11:49:05Z","timestamp":1513770545000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-4988","authenticated-orcid":false,"given":"Keshavamurthy","family":"Vinay","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Yanamandra","sequence":"additional","affiliation":[{"name":"Department of 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