{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:55:45Z","timestamp":1788396945984,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypopigmented mycosis fungoides (<jats:styled-content style=\"fixed-case\">hMF<\/jats:styled-content>) is a rare subtype of mycosis fungoides. The aim of this study was to identify the clinical\u2013epidemiological profile of our patient group and also to provide additional information about treatment responses and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional retrospective observational study, with exploratory analysis. The outcome variables were disease progression and related death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients with <jats:styled-content style=\"fixed-case\">hMF<\/jats:styled-content> were selected from a group of 102 patients diagnosed with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. There was no gender difference (10 females and 10 males). Mean age at diagnosis was 43.85\u00a0years, and most patients had mixed or black skin color. The mean time between the onset of the lesions and the diagnosis was 66.75\u00a0months. Patients were equally distributed in stages <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> (50%) and <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> (50%). Photochemotherapy (psoralen and ultraviolet A) was the predominant therapeutic modality. The mean follow\u2010up time was 7.25\u00a0years. In 10%, disease progression was observed. Death related to the disease occurred in one patient<jats:italic><jats:bold>.<\/jats:bold><\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical and epidemiological profile of patients with hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> found in our sample is in agreement with what is described in the literature, with the exception of the age at diagnosis, higher than expected. Diagnostic delay time, despite long, is also consistent with the medical literature; however, in this sample, we had two cases of disease progression, with death of one patient, despite the treatment, which is extremely important since hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> is usually associated with good prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13855","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:07:22Z","timestamp":1515593242000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hypopigmented mycosis fungoides: a 20\u2010case retrospective series"],"prefix":"10.1111","volume":"57","author":[{"given":"Gustavo M.","family":"Amorim","sequence":"first","affiliation":[{"name":"Sector of Dermatology and Post Graduation Program in Medical Clinics HUCFF\u2010UFRJ and School of Medicine Federal University of 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