{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:15:23Z","timestamp":1792656923805,"version":"4.5.0"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The literature includes only a few reports of oral isotretinoin for the treatment of folliculitis decalvans (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>). This study aimed to determine the most effective dose and duration of oral isotretinoin monotherapy for achieving remission in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective case series study included <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients that were treated with oral isotretinoin. Patient demographics, clinical characteristics, and treatment details were obtained from the patients\u2019 medical records. Patients were contacted via telephone after treatment was completed and asked about any relapses, time period of relapses, and the long\u2010term effects of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 39 male patients with a mean age of 37.9 \u00b1 15.5 years. All of the patients received oral isotretinoin 0.1\u20131.02 mg\/kg\/day (10\u201390 mg\/day) for a median duration of 2.5 months (range: 1\u20138 months). In all, 82.0% of patients healed after the treatment. Patients that received oral isotretinoin \u22650.4 mg\/kg\/day for \u22653 months responded better, and 66% of them never relapsed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrary to general belief, oral isotretinoin monotherapy resulted in complete response in the majority of patients in this study. Based on this finding, we think oral isotretinoin \u22650.4 mg\/kg\/day should be given for \u22653 months to minimize the likelihood of relapse. In addition, we think oral isotretinoin monotherapy should be considered a promising treatment alternative for <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> that warrants further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13874","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T05:02:49Z","timestamp":1515042169000},"page":"250-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Isotretinoin treatment for folliculitis decalvans: a retrospective case\u2010series study"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-1865","authenticated-orcid":false,"given":"Berna","family":"Aksoy","sequence":"first","affiliation":[{"name":"School of Medicine Dermatology Department Bahcesehir University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Hapa","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Buca Seyfi Demirsoy State Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology Celal Bayar University Manisa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00204.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.13218"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13052"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03616.x"},{"key":"e_1_2_7_6_1","first-page":"184","article-title":"Folliculitis decalvans of the scalp: response to triple therapy with isotretinoin, clindamycin, and prednisolone","volume":"15","author":"Gemmeke A","year":"2006","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12993"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:18:10Z","timestamp":1695957490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ijd.13874"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13874","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,4]]},"assertion":[{"value":"2018-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}