{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:19:16Z","timestamp":1784222356452,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the effectiveness and outcomes of adjuvant radiotherapy regimens for nonmelanoma skin cancers (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>) of the head and neck, particularly for elderly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of patients with head and neck <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> was conducted. Radiotherapy dose per fraction regimens included \u2264200, 240\u2013250, 300\u2013400, and 500\u2013600 cGy. Demographics, tumor characteristics, local control (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>), regional control (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>), and survival outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 90 patients with 140 disease sites, 76.6% were squamous cell carcinoma, 15.5% were basal cell carcinoma, and 7.7% were other histologies. The mean age at diagnosis was 72.1 years old. The most common location was preauricular (20.0%), followed by temple, scalp, cheek, and forehead. The overall <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> rates were 88.8% and 88.8%, respectively by patients, and 92.8% and 86.4%, respectively by treatment sites. Age, primary tumor location, T classification, N classification, overall stage, perineural invasion, comorbid disease, skull base invasion, and radiotherapy subgroup were significantly associated with disease\u2010free and overall survival (<jats:italic>P<\/jats:italic> &lt; 0.05). <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> were not significantly different among the radiotherapy dose subgroups. The mean survival was longer in patients treated with 240\u2013250 cGy\/fraction (50.3 months). There was no significant difference in radiotherapy toxicity between the subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Short\u2010term radiotherapy regimens for patients with locally or regionally advanced head and neck <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> appear feasible and effective, particularly in elderly patients or those that cannot tolerate the length of standard regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13879","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:48:44Z","timestamp":1516636124000},"page":"441-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiotherapy regimens in patients with nonmelanoma head and neck skin cancers"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-2682","authenticated-orcid":false,"given":"Yusuf","family":"Dundar","sequence":"first","affiliation":[{"name":"Otolaryngology \u2013 Head &amp; Neck Surgery Rize Government Hospital Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Monroe","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Suneja","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Huntsman Cancer Hospital University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying J.","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Huntsman Cancer Hospital University of Utah Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.19"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103293441306"},{"key":"e_1_2_6_4_1","first-page":"1773","volume-title":"Dermatology","author":"Soyer HP","year":"2012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9296-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24296"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24542"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24679"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812438170"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.12.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2015.35.e513"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70178-5"},{"key":"e_1_2_6_13_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology.Basal Cell and Squamous Cell Skin Cancers. Version 2.2012.http:\/\/www.nccn.org\/professionals\/physician_gls\/f_guidelines.asp. Accessed November 27 2015."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.02.024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01656-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.02.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12319"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.108"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.004"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:25:37Z","timestamp":1695612337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/ijd.13879"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13879","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"assertion":[{"value":"2016-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}