{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:56:53Z","timestamp":1785185813149,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is an acquired pigmentary skin of depigmentation occurring secondary to melanocyte destruction. Vitiligo and other leukodermas have a profound impact on quality of life. Current therapies include medical options, such as phototherapy, topical and systemic corticosteroids, topical calcineurin inhibitors, immunomodulators, and antioxidiants, and surgical options. Surgical options provide melanocytic cells to previously depigmented areas and use either tissue grafting or cellular grafting methods. Topical treatments are often insufficient, and many of the current surgical procedures have shown variable response rates. In this review, we discuss the process of the cellular grafting melanocyte\u2010keratinocyte transplantation procedure (<jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content>) and critically analyze its efficacy and safety in the treatment of vitiligo and other leukodermas. PubMed was searched for studies (2001\u20132017) describing the use of <jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content> in patients with vitiligo or other leukodermas. Articles or trials discussing the use of <jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content> for these patients were selected for in\u2010depth review. Clinically relevant results regarding efficacy and safety of <jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content> in vitiligo and leukoderma patients were analyzed. Numerous trials and case series\/reports have demonstrated tolerability and efficacy of <jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content> with repigmentation for patients with refractory, stable vitiligo. However, the response rates have been variable, likely influenced by vitiligo type and affected areas. Future research and clinical reporting will provide more insight on which phenotypes may benefit from <jats:styled-content style=\"fixed-case\">MKTP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijd.13895","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:07:24Z","timestamp":1515593244000},"page":"770-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of noncultured melanocyte\u2010keratinocyte transplant procedure for vitiligo and other leukodermas: a critical analysis of the evidence"],"prefix":"10.1111","volume":"57","author":[{"given":"Paras P.","family":"Vakharia","sequence":"first","affiliation":[{"name":"Oakland University William Beaumont School of Medicine Royal Oak MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amor","family":"Khachemoune","sequence":"additional","affiliation":[{"name":"Dermatology Service Veterans Affairs Hospital &amp; SUNY Downstate Medical Center Brooklyn NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01139.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2010.08.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.01.056"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08815.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5070\/D313D68647","article-title":"Linear rays of hypopigmentation following intra\u2010articular corticosteroid injection for post\u2010traumatic degenerative joint disease","volume":"18","author":"Schwartz C","year":"2012","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06755.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12843"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.043"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.002"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12532"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70024-A"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02177.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14204"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.79181"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.53194"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12674"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.14061"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12134"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132054"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03946.x"},{"key":"e_1_2_5_25_1","first-page":"1032","article-title":"Treatment of vitiligo with a melanocyte\u2010keratinocyte cell suspension versus dermabrasion only: a pilot study with a 12\u2010month follow up","volume":"10","author":"Vazquez\u2010Martinez OT","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03759.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.90947"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01628.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.10.1211"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32109.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02226.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.2310\/6350.2005.31324"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08216.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10398.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34384.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01045.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.013"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.79183"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001190"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.238"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2013.09.004"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.172904"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1034068"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1034-7"},{"key":"e_1_2_5_45_1","first-page":"1203","article-title":"Double\u2010blind placebo\u2010controlled study of autologous transplanted epidermal cell suspensions for repigmenting vitiligo","volume":"140","author":"Geel N","year":"2004","journal-title":"Arch Dermatol"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.13895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.13895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:04:22Z","timestamp":1695477862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.13895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/ijd.13895"],"URL":"https:\/\/doi.org\/10.1111\/ijd.13895","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]},"assertion":[{"value":"2017-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}