{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:59:55Z","timestamp":1778853595183,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although concerns have been raised regarding the long\u2010term health risks of offspring conceived following fertility treatments, limited information is available regarding their health status beyond the neonatal period. We aimed to evaluate the risk of long\u2010term eruptive dermatological morbidity among children born following fertility treatments as compared to those conceived spontaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study was conducted, including all singleton deliveries occurring between the years 1991 and 2014 at a single tertiary medical center. Fetuses with congenital malformations and multiple gestations were excluded. Children delivered following fertility treatment pregnancies and spontaneous pregnancies were compared. Hospitalizations of the offspring up to the age of 18\u00a0years involving cutaneous eruptions were evaluated. A Kaplan\u2013Meier survival curve was used to compare cumulative morbidity incidence and a Cox regression model to control for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 242,187 singleton deliveries met the inclusion criteria, 1.8% of which were following fertility treatments (<jats:italic>n<\/jats:italic>\u00a0=\u00a04324). Eruptive dermatological morbidity of the offspring up to the age of 18\u00a0years was significantly more common in the fertility treatment group (1.5%) as compared to spontaneous pregnancies (1.1%; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023). The Kaplan\u2013Meier survival curve demonstrated a significantly higher cumulative incidence of eruptive dermatological morbidity following fertility treatments (log\u2010rank <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007). Using the Cox regression model, while controlling for multiple confounders, fertility treatment was noted as an independent risk factor for long\u2010term pediatric eruptive dermatological morbidity (adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a01.43, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.12\u20131.83, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Singletons conceived via fertility treatments appear to be at an increased risk for long\u2010term eruptive dermatological morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13903","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T11:20:04Z","timestamp":1516879204000},"page":"317-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term pediatric skin eruption\u2010related hospitalizations in offspring conceived via fertility treatment"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-4014","authenticated-orcid":false,"given":"Yuval","family":"Krieger","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva 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