{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T06:18:56Z","timestamp":1774073936531,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histoid leprosy (HL) is a rare form of lepromatous leprosy, characterized by hyperchromic indurated nodules above normal skin. Its main histopathological aspect is spindle cells. Because it may simulate other aspects, such as dermatofibroma and neurofibroma, histoid leprosy poses itself as a diagnostic challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study with all patients having been selected from the leprosy clinic of the Hospital das Cl\u00ednicas da Universidade de S\u00e3o Paulo from 2006 to 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 12 patients in this study, eight in the histoid group and four in the lepromatous leprosy group. The prevalence of HL was 1.12% in all leprosy subjects. All individuals from HL group were \u201c<jats:italic>de novo<\/jats:italic>\u201d cases, and the histopathological analysis of skin lesions presented spindle cells generating a storiform pattern. Immunohistochemistry for CD68, vimentin, and anti\u2010BCG were positive in all 12 cases. Factor XIIIa was visualized only in the papillary dermis, and S100 protein was negative in all biopsies. Smooth\u2010muscle actin was present in 62.5% of the HL samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of HL was similar to previous reports. However, all histoid patients were \u201c<jats:italic>de novo<\/jats:italic>\u201d cases<jats:italic>,<\/jats:italic> differing from published studies. Fusocellular macrophage transformation could be explained by the differences in cytoskeleton proteins expressed in histoid lesions in comparison to other leprosy variants, with emphasis on vimentin and smooth muscle actin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13926","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T16:24:51Z","timestamp":1517415891000},"page":"707-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Histoid leprosy: clinical and histopathological analysis of patients in follow\u2010up in University Clinical Hospital of endemic country"],"prefix":"10.1111","volume":"57","author":[{"given":"Maria J. 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B.","family":"Trindade","sequence":"additional","affiliation":[{"name":"Scientific researcher VI of Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica, Imunodermatologia Instituto de Sa\u00fade da Secretaria de Estado da Sa\u00fade do Estado de S\u00e3o Paulo do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-6373","authenticated-orcid":false,"given":"Joao","family":"Avancini","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Cl\u00ednica Dermatol\u00f3gica do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Pagliari","sequence":"additional","affiliation":[{"name":"Departamento de Patologia da Faculdade de Medicina da Universidade de S\u00e3o Paulo Sao Paulo 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