{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:35:23Z","timestamp":1764102923443,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Folliculotropic mycosis fungoides (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>) is a cutaneous T\u2010cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore a possible role of immune privilege (IP) in <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> analyzing the major histocompatibility complex (MHC) expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G and MHC\u2010II was performed to formalin\u2010fixed paraffin\u2010embedded cutaneous skin biopsies of <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic> = 43), conventional mycosis fungoides (<jats:styled-content style=\"fixed-case\">CMF<\/jats:styled-content>;<jats:italic> n<\/jats:italic> = 13), alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>;<jats:italic> n<\/jats:italic> = 13), and normal scalp skin (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>;<jats:italic> n<\/jats:italic> = 12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G expression was lower in <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> (34%: 14\/41) and <jats:styled-content style=\"fixed-case\">CMF<\/jats:styled-content> (18%: 2\/11) groups compared to alopecia areata (92%:11\/12) and normal scalp skin group (100%: 12\/12). MHC\u2010II expression in hair follicle was greater in the <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> group (18\/42: 43%) compared to <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> (0%) and <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> (0%). <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G and MHC\u2010II expression in cellular infiltrate had no difference among <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CMF<\/jats:styled-content> groups and was different compared to the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support the hypothesis of disruption of immune privilege based on the lower expression of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G and higher expression of MHC\u2010II in the follicular epithelium in mycosis fungoides compared to alopecia areata and normal scalp skin. The lack of difference between <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CMF<\/jats:styled-content> groups did not support the role of these molecules as a driver of folliculotropism. The expression of <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> molecules seems to be different between neoplastic and inflammatory infiltrates. The definitive significance of expression of the <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> molecules remains unclear, and more studies are necessary to fully understand the role of these molecules in cutaneous lymphomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13967","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T01:07:06Z","timestamp":1522458426000},"page":"675-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-7186","authenticated-orcid":false,"given":"Janyana M. 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