{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:35:35Z","timestamp":1785893735882,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The earlier detection of melanomas occurring within preexisting nevi is theoretically possible using sequential dermoscopy. Characterizing the early follow\u2010up changes of nevus\u2010associated melanomas (<jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s) and differentiating them from those observed in <jats:italic>de novo<\/jats:italic> melanomas (<jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s) may help the earlier recognition of <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using descriptive dermoscopic features to detect focal changes, we blindly evaluated retrospectively the baseline and follow\u2010up images of 32 melanomas that were subsequently classified as histopathologically defined <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s or <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Correlates of growth, as structureless brown\u2010black areas or clods, complemented each other for the identification of <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s at baseline (structureless brown\u2010black areas: 66.7% <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s, 15% <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01; combined with dots, one or the other being present: 100% <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s, 30% <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01) and when considering their baseline presence or their appearance at follow\u2010up (100% <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s, 35% <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Correlates of fibrosis, as white lines, when considering their baseline presence or their appearance at follow\u2010up, were associated with <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s (60%, 16.7% <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant differences, distinguishing <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s from <jats:styled-content style=\"fixed-case\">DNM<\/jats:styled-content>s, were detected particularly when considering both baseline signs and follow\u2010up changes. Earlier identification of <jats:styled-content style=\"fixed-case\">NAM<\/jats:styled-content>s and their subsequent improved histological characterization will help define the subgroup of high\u2010risk patients, for whom comprehensive image monitoring may be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13977","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T05:04:43Z","timestamp":1522731883000},"page":"692-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recognition of early melanoma: a monocentric dermoscopy follow\u2010up study comparing <i>de novo<\/i> melanoma with nevus\u2010associated melanoma"],"prefix":"10.1111","volume":"57","author":[{"given":"David","family":"Alvarez Martinez","sequence":"first","affiliation":[{"name":"Division of Dermatology and Venereology University Hospital of Geneva Geneva 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