{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:20:20Z","timestamp":1790742020395,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:00:00Z","timestamp":1522454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24\u00a0years. Very few data about patients with early\u2010onset HS exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association of early\u2010onset HS with the clinical characteristics: age, gender, body mass index (BMI), smoking, family history of HS, Hurley stage, and number of areas affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of the reported early age at HS onset (\u226417\u00a0years old) with clinical characteristics and with the severity of HS at first consultation visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 166 patients, 42 patients (25.3%) reported early\u2010onset HS. Compared to adult\u2010onset HS, patients with early\u2010onset HS were younger (mean age: 37\u00a0years vs. 27\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), had a significantly younger mean age of onset (28.2\u00a0years old vs. 14.5\u00a0years old, respectively, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), longer mean disease duration (8.8\u00a0years vs. 12.6\u00a0years, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) and were less frequently smokers (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), whereas there was no association with gender (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.177) or BMI (0.086). Patients with a family history had increased risk for early\u2010onset HS (OR: 2.45, 95% CI: 1.08\u20135.56). Early\u2010onset HS was not associated with Hurley stage (OR: 1.12, 95% CI: 0.33\u20133.74) or with the number of body areas affected (OR: 1.54, 95% CI: 0.49\u20134.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early\u2010onset HS was frequent and associated with a family history of HS. There was no difference in the severity of HS in adult life for patients with an onset of HS at \u226417\u00a0years, compared to patients with adult\u2010onset, which may be reassuring information for these younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.13985","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T14:41:17Z","timestamp":1522507277000},"page":"687-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A retrospective study of the characteristics of patients with early\u2010onset compared to adult\u2010onset hidradenitis suppurativa"],"prefix":"10.1111","volume":"57","author":[{"given":"Clio","family":"Dessinioti","sequence":"first","affiliation":[{"name":"1st Department of Dermatology A.Syggros Hospital University of Athens Athens 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