{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:31Z","timestamp":1787014351951,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dipeptidyl peptidase\u20104 (DPP\u20104) inhibitors have increasingly been identified as causative agents of bullous pemphigoid. The clinical and immunological characteristics of this pemphigoid variant are still unclear. The objective of our study was to analyze the clinical and immunological features of patients with pemphigoid induced by DPP\u20104 inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients diagnosed with DPP\u20104 inhibitor\u2010associated bullous pemphigoid at dermatology departments in three Spanish centers during the period 2013 to 2015 were included. ELISA assays for the NC16A domain of BP180 and BP230 were performed. Immunoblot studies using epidermal\/dermal extracts and the C\u2010terminal, NC16A and LAD\u20101 regions of BP180 were also carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of eight patients were identified (5 treated with vildagliptin, 2 with linagliptin, and one with sitagliptin). Of these, four presented the classical inflammatory phenotype of bullous pemphigoid and four a noninflammatory phenotype. The ELISA for BP180 (NC16A domain) was positive in six patients at diagnosis. Most patients reacted to more than one BP180 antigenic site (LAD\u20101 and\/or C\u2010terminal domain) on the immunoblot. Two patients showed no reaction against the NC16A domain of BP180 on either the ELISA or immunoblot but recognized either LAD\u20101 or both LAD\u20101 and the C\u2010terminal domain. Only one of the NC16A\u2010negative patients had a noninflammatory subtype of bullous pemphigoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with DPP\u20104 inhibitor\u2010induced BP may present either an inflammatory or a noninflammatory phenotype of BP. IgG response against other BP180 regions different from the NC16A domain, such as LAD\u20101 and the C\u2010terminal domain, could be pathogenically relevant to the onset of DPP\u20104 inhibitor\u2010induced BP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.14005","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T03:34:48Z","timestamp":1524454488000},"page":"810-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bullous pemphigoid induced by dipeptidyl peptidase\u20104 inhibitors. Eight cases with clinical and immunological characterization"],"prefix":"10.1111","volume":"57","author":[{"given":"Irene","family":"Garc\u00eda\u2010D\u00edez","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Parc de Salut Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ivars\u2010Lle\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, University Clinic of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"L\u00f3pez\u2010Avent\u00edn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Parc de Salut Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Parc de Salut Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Espa\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, University Clinic of Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep E.","family":"Herrero\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Parc de Salut Mar Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.03.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00033.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12366"},{"key":"e_1_2_6_5_1","first-page":"32100","article-title":"Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid","volume":"14","author":"Izumi K","year":"2016","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04062.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0804"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443330"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14601"},{"key":"e_1_2_6_10_1","unstructured":"World Health Organization (WHO).Uppsala Monitoring Centre: The Use of the WHO\u2010UMC system for standardized case causality assesment. 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