{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:25:46Z","timestamp":1782595546189,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9309184508"],"award-info":[{"award-number":["9309184508"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta\u2010catenin (\u03b2\u2010catenin) and CD<\/jats:styled-content>44 expression in oral lichen planus (OLP<\/jats:styled-content>) as a condition with malignant potential and oral squamous cell carcinoma (OSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>\u03b2\u2010Catenin and CD<\/jats:styled-content>44 expression were evaluated in 15 patients with epithelial hyperplasia (group A), 20 OLP<\/jats:styled-content> (group B), and 20 OSCC<\/jats:styled-content> (group C) by immunohistochemistry.<\/jats:p><\/jats:sec>Results<\/jats:title>Quantitative and semi\u2010quantitative evaluations revealed \u03b2\u2010catenin, and CD<\/jats:styled-content>44 membranous expression had significant differences among the three groups. Expression of these markers in the OSCC<\/jats:styled-content> group decreased significantly compared to that of the OLP<\/jats:styled-content>. Also, nuclear\/cytoplasmic expression of \u03b2\u2010catenin was significantly different among the three groups, considering that nuclear expression was not observed in any of the epithelial hyperplasia and OLP<\/jats:styled-content> samples.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>According to the findings of this study, \u03b2\u2010catenin and CD<\/jats:styled-content>44 can differentiate between behavior of OLP<\/jats:styled-content> and OSCC<\/jats:styled-content>, while the precancerous nature of OLP<\/jats:styled-content> and malignant transformation potential of it are not suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14007","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T05:30:47Z","timestamp":1524634247000},"page":"794-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative study of \u03b2\u2010catenin and CD<\/scp>44 immunoexpression in oral lichen planus and squamous cell carcinoma"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-2590","authenticated-orcid":false,"given":"Massoumeh","family":"Zargaran","sequence":"first","affiliation":[{"name":"Dental Research Center Department of Oral & Maxillofacial Pathology School of Dentistry Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Baghaei","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Pathology School of Dentistry Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Moghimbeigi","sequence":"additional","affiliation":[{"name":"Modeling of Noncommunicable Diseases Research Center Department of Biostatistics School of Public Health Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.05.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.08.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0346-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.11.6979"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.00147.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300347200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0156"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol_00000077"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067361"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64863-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_6_13_1","first-page":"E224","article-title":"Letter to the editor: oral lichenoid disease. 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