{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:36:32Z","timestamp":1778024192563,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pigmented lesions on the lips can be caused by physiological or pathological factors, along with exogenous or endogenous factors. Many patients with atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and labial pigmentation are seen in clinical practice. The aim of our study was to further explore the association of labial pigmentation and <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of patients who visited the Department of Dermatology at Kyung Hee Medical Center, Seoul, Korea, from January 1 to December 31, 2016. The study consisted of 178 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and a control group of 178 age\u2010 and sex\u2010matched patients without <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> had both a significantly higher prevalence of labial pigmented lesions and a significantly higher number of labial pigmented lesions than was observed in the control group. Moreover, the pigmented lesions were found mainly in the middle section of the upper lip and showed multifocal distribution. The patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and labial pigmentation were significantly younger at the onset of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, showed a greater association with allergic disorder, and had a higher immunoglobulin E (IgE) level than patients without labial pigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings strongly suggest that labial pigmentation occurs in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Although labial pigmentation was not present in all patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, this might be a particularly helpful diagnostic feature of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in Asian patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14010","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T07:25:31Z","timestamp":1524468331000},"page":"817-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Atopic labial pigmentation: a new diagnostic feature in Asian patients with atopic dermatitis"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-122X","authenticated-orcid":false,"given":"In\u2010Hye","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Kyung Hee University Seoul 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