{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:10:30Z","timestamp":1789513830817,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T00:00:00Z","timestamp":1524960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alpha\u20101 antitrypsin deficiency (AATD) may be associated with liver and lung disease and rarely causes panniculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We evaluated the clinicopathologic and laboratory findings of AATD panniculitis in 10 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of all cases of AATD panniculitis at Mayo Clinic, Rochester, MN, from 1989 to 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten patients with AATD panniculitis were included. Seven of ten were women. Clinical lesions were most commonly nodular (100%), erythematous (90%), ulcerated (90%), and painful (90%) subcutaneous nodules and plaques. Extracutaneous associations were rare. PiZZ phenotype was most commonly identified (50%). Histopathologically, lobular panniculitis (80%) with associated septal involvement (60%) and a predominant neutrophilic infiltrate (100%) were most common. Treatments varied; dapsone and alpha\u20101 proteinase inhibitor infusions were each used in five (50%) patients, respectively. In patients with greater than 6\u2010month follow\u2010up (<jats:italic>n<\/jats:italic> = 4), one patient continued to have disease activity despite treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AATD panniculitis should be considered in the differential for a painful, ulcerative panniculitis with a predominantly neutrophilic histopathologic infiltrate. Diagnosis can be made with clinicopathologic correlation and genetic and laboratory evaluations. Serum AAT level and phenotype assists in diagnosing patients with suspected AATD panniculitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14012","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T05:10:23Z","timestamp":1525065023000},"page":"952-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Alpha\u20101 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-1771","authenticated-orcid":false,"given":"Emma F.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-1649","authenticated-orcid":false,"given":"Stanislav N.","family":"Tolkachjov","sequence":"additional","affiliation":[{"name":"Surgical Dermatology Group Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"},{"name":"Division of Dermatopathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.03.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.04.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.053"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14309"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.05.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0270-CC"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198712000-00003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0002-9343(88)90163-5","article-title":"Alpha\u20101\u2010antitrypsin deficiency and panniculitis. 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