{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:56:45Z","timestamp":1780462605087,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermal hyperproliferation with abnormal differentiation, inflammation, and angiogenesis are the key features of psoriasis. Glucose transporter\u20101 (<jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101) is a member of facilitative sugar transporters that are integral membrane glycoproteins moving sugar across cell membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to study the <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 expression in psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Forty patients with psoriasis vulgaris and 20 healthy individuals were included in the study. Skin biopsies were taken from lesional and nonlesional skin of psoriasis patients as well as normal skin of control subjects. All were examined for <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 antibody expression by immunohistochemistry and <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression by real\u2010time polymerase chain reaction (RT\u2010PCR). In addition, specimens of psoriasis lesions were stained by hematoxylin and eosin and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>31 for morphometric analysis of histopathological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intensity of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 immunohistochemical expression and the relative levels of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in psoriasis lesions were upregulated in lesional skin of psoriasis patients in comparison with their nonlesional skin as well as normal control skin. <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 expression in psoriasis lesions showed significant positive correlations with Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) score, mean of epidermal thickness, inflammatory cell density, and microvessel density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glucose transporter\u20101 could play a role not only in the onset of psoriasis but also in the progression and severity of the disease. It may participate in the pathogenesis of psoriasis through the facilitation of epidermal hyperproliferation, inflammation, and angiogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14037","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T06:30:40Z","timestamp":1527229840000},"page":"943-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Glucose transporter\u20101 (<scp>GLUT<\/scp>\u20101) expression in psoriasis: correlation with disease severity"],"prefix":"10.1111","volume":"57","author":[{"given":"Abeer A.\u2010H.","family":"Hodeib","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yomna M.E.\u2010H.","family":"Neinaa","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Faculty of Medicine Tanta University Tanta 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