{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:23:08Z","timestamp":1791894188769,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypohidrotic Ectodermal Dysplasia (<jats:styled-content style=\"fixed-case\">HED<\/jats:styled-content>) is a genetic human disorder which affects structures of ectodermal origin. Although there are autosomal recessive and dominant forms, X\u2010linked (<jats:styled-content style=\"fixed-case\">XL<\/jats:styled-content>) is the most frequent form of the disease. This <jats:styled-content style=\"fixed-case\">XL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HED<\/jats:styled-content> phenotype is associated with mutations in the gene encoding the transmembrane protein ectodysplasin\u20101 (<jats:italic><jats:styled-content style=\"fixed-case\">EDA<\/jats:styled-content>1<\/jats:italic>), a member of the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>\u2010related signaling pathway. The proteins from this pathway are involved in signal transduction from ectoderm to mesenchyme leading to the development of ectoderm\u2010derived structures in the fetus such as hair, teeth, skin, nails, and eccrine sweat glands. The aim of this review was to update the main clinical characteristics of <jats:styled-content style=\"fixed-case\">HED<\/jats:styled-content> regarding to recent molecular advances in the comprehension of all the possible genes involved in this group of disorders since it is known that Eda\u2010A1\u2010Edar signaling has multiple roles in ectodermal organ development, regulating their initiation, morphogenesis, and differentiation steps. The knowledge of the biological mechanisms that generate <jats:styled-content style=\"fixed-case\">HED<\/jats:styled-content> is needed for both a better detection of possible cases and for the design of efficient prevention and treatment approaches.<\/jats:p>","DOI":"10.1111\/ijd.14048","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T04:49:42Z","timestamp":1527828582000},"page":"965-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Hypohidrotic ectodermal dysplasia: clinical and molecular review"],"prefix":"10.1111","volume":"57","author":[{"given":"Julia","family":"Reyes\u2010Reali","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Facultad de Estudios Superiores Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico Tlalnepantla Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda 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