{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:19:18Z","timestamp":1792718358924,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemotherapy\u2010induced skin sclerosis is generally not associated with other manifestations of systemic sclerosis. It is featured by skin sclerosis without visceral involvement (i.e., Raynaud's phenomenon, esophageal dysmotility, and pulmonary fibrosis), temporal association with chemotherapy administration, and the absence of detectable autoantibodies. The clinical course of scleroderma\u2010like changes induced by paclitaxel or gemcitabine are refractory to treatment and commonly progressive, even after discontinuation of the triggering drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Report a case of scleroderma\u2010like cutaneous lesions during combination treatment with nab\u2010paclitaxel and gemcitabine in a patient with pancreatic adenocarcinoma and determine other published cases of scleroderma\u2010like skin changes following treatment with nab\u2010paclitaxel, paclitaxel, or gemcitabine through the period from 2002 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search from the year 2002 onwards using combinations of \u201cScleroderma\u201d <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> \u201cpaclitaxel,\u201d <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> \u201cgemcitabine.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Additional to our case report we reviewed 14 other cases in the literature. Most of these cases share three prominent features: skin sclerosis without systemic involvement, temporal association with chemotherapy administration, and absence of detectable scleroderma\u2010specific autoantibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first case report of scleroderma\u2010like cutaneous lesions during combination treatment with nab\u2010paclitaxel and gemcitabine in a patient with pancreatic adenocarcinoma. However, given the current literature, these scleroderma\u2010like lesions are most likely induced by nab\u2010paclitaxel or paclitaxel, rather than by gemcitabine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14067","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T10:14:16Z","timestamp":1529921656000},"page":"1075-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Scleroderma\u2010like cutaneous lesions during treatment with paclitaxel and gemcitabine in a patient with pancreatic adenocarcinoma. Review of literature"],"prefix":"10.1111","volume":"57","author":[{"given":"Lien","family":"Verhulst","sequence":"first","affiliation":[{"name":"Department of Dermatology AZ Delta Hospital and private practice Roeselare Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"No\u00eb","sequence":"additional","affiliation":[{"name":"Department of Dermatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Anne","family":"Morren","sequence":"additional","affiliation":[{"name":"Department of Dermatology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Verslype","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology UZ Leuven and KULeuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Van Cutsem","sequence":"additional","affiliation":[{"name":"Department of Digestive 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