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The patients were randomly allocated to receive four laser sessions with 2 weeks interval. Control side received long pulsed Nd : YAG laser (1064 nm) only, and the other side (combined treatment side) received combined fractional CO<jats:sub>2<\/jats:sub> laser and long pulsed Nd : YAG (1064 nm) laser. Patients were clinically and histopathologically evaluated 2 weeks post treatment. Recurrence was evaluated 3 months post treatment. Outcome was clinically evaluated by physician global assessment (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>), 10\u2010point visual analog scale for patient's satisfaction, and side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant higher improvement and patient's satisfaction was observed in combined treatment side compared with control side (<jats:italic>P<\/jats:italic> = 0.011, 0.048 respectively). Absence of recurrence was achieved by 55% of sides receiving combined treatment and 35% of control sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination of fractional CO<jats:sub>2<\/jats:sub> laser and long pulsed Nd : YAG (1064 nm) laser in treatment of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> had higher improvement and patient's satisfaction together with lower recurrence compared with long pulsed Nd : YAG (1064 nm) laser alone. Better results could be achieved with low <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>, non\u2010obese populations, and absence of surgeries for the lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14075","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T08:49:50Z","timestamp":1529138990000},"page":"1135-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Combined fractional carbon dioxide laser and long\u2010pulsed neodymium : yttrium\u2010aluminium\u2010garnet (1064 nm) laser in treatment of hidradenitis suppurativa; a prospective randomized intra\u2010individual controlled study"],"prefix":"10.1111","volume":"57","author":[{"given":"Amira A.","family":"Abdel Azim","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls Al\u2010Azhar University Cairo 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