{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:22:53Z","timestamp":1782494573394,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical cantharidin is a commonly used treatment for molluscum contagiosum (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>). However, studies validating its safety and efficacy are limited. We conducted a 6\u2010week, randomized, double\u2010blind, placebo\u2010controlled trial with subsequent open\u2010label extension to assess the safety and effectiveness of cantharidin in treating pediatric <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>. Ninety\u2010four participants with <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> were randomized to receive cantharidin or placebo, with or without occlusion. The primary outcome was complete lesion clearance. Secondary outcomes included post\u2010treatment lesion count, adverse events, and side effects. No significant differences between the study arms, including baseline lesion count, were observed. The overall mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) baseline lesion count was 22.2 (12.9). The number of participants achieving total clearance is as follows: 7\/23 (30.4%) in the cantharidin only arm, 10\/24 (41.7%) in the cantharidin with occlusion arm, 2\/25 (8.0%) in the placebo with occlusion arm, and 3\/22 (13.6%) in the placebo only arm. Post hoc analysis demonstrated that 17\/47 (36.2%) participants in the combined cantharidin arms achieved clearance compared to 5\/47 (10.6%) in the placebo arms (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0065). The mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) lesion count change from baseline was \u22125.1 (12.2) in the placebo only arm; the mean change (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) was \u221217.4 (12.8) in the cantharidin only arm (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0033) and \u221215.9 (11.6) in the cantharidin with occlusion arm (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0101). No serious adverse events or side effects were observed. Topical cantharidin was well\u2010tolerated and associated with the resolution of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijd.14079","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T08:39:59Z","timestamp":1529051999000},"page":"1001-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double\u2010blind, placebo\u2010controlled pilot trial"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-1852","authenticated-orcid":false,"given":"Anthony K.","family":"Guzman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Schairer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Albert Einstein College of Medicine Bronx NY USA"},{"name":"Department of Dermatology University of California San Diego School of Medicine La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Garelik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Albert Einstein College of Medicine Bronx NY 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