{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:22Z","timestamp":1787014342412,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>5\u2010fluorouracil (5\u2010FU) has proven to be an effective therapy in the treatment of a variety of dermatologic conditions. Approved by the United States Food and Drug Administration for the treatment of actinic keratoses and superficial basal cell carcinoma, topical 5\u2010FU has also demonstrated efficacy in the treatment of a variety of other dermatologic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A search of the\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      standard computer database,\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      advanced database, and\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      database was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010four articles met criteria for inclusion in this review. These articles represented 16 randomized controlled trials and 18 case series. Each article was reviewed and summarized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Topical 5\u2010FU is used in a variety of dermatologic disease processes with a wide range of efficacy and levels of evidence. Based on extent and level of evidence, our disease\u2010specific systematic review found that the evidence is strongest for topical 5\u2010\n                      <jats:styled-content style=\"fixed-case\">FU<\/jats:styled-content>\n                      use in the treatment of actinic keratosis, squamous cell carcinoma, and basal cell carcinoma. This review serves as a comprehensive summary of topical 5\u2010FU use in dermatology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.14106","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T06:26:53Z","timestamp":1529908013000},"page":"1259-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Topical 5\u2010fluorouracil in dermatologic disease"],"prefix":"10.1111","volume":"57","author":[{"given":"Garrett T.","family":"Prince","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Fathi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Alkousakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(90)90056-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_2_6_4_1","first-page":"153","article-title":"Tumors of the skin. 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