{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:17:00Z","timestamp":1790223420379,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is currently known about health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) of patients with cutaneous T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>), a condition characterized by chronic, pruritic, visible lesions, features which may be uniquely influential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to establish baseline <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL data for patients with <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> and identify its influencing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, nonblinded survey design utilizing questionnaires including panels of QoL indices obtained from 105 patients with mycosis fungoides, Sezary syndrome, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ lymphoproliferative disorder. Chart\u00a0review correlated QoL with year of disease onset\/diagnosis, type\/stage of disease, current\/past therapies, and medical\/psychiatric diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psychiatric condition was significantly associated with symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), emotions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and functioning (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.03) subscales along with overall composite measure (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). High\u2010grade systemic therapy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a05.28) showed greater increase in odds of a lower health state than low grade (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.54). The number of medical comorbidities was significantly related to itching (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Increased age was a protective factor with respect to the emotions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), functioning (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and overall composite (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) but not predictive of symptoms. Lower income was associated with higher bother on the symptoms subscale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> appears related to a number of factors, including presence of a psychiatric condition, use of systemic (particularly high grade) therapy, number of medical comorbidities, and income.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14132","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:21:53Z","timestamp":1533619313000},"page":"1314-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Health\u2010related quality of life in patients with cutaneous T\u2010cell lymphoma?"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1543-4341","authenticated-orcid":false,"given":"Heather M.","family":"Holahan","sequence":"first","affiliation":[{"name":"Rutgers\u2010New Jersey Medical School Department of Dermatology University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronda S.","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fitz","sequence":"additional","affiliation":[{"name":"Medical Associates Clinic &amp; Health Plans Dubuque IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Mott","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics Holden Comprehensive Cancer Center Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkanyezi N.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"McKillip","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\u2010Hematology, Oncology, and Blood and Marrow Transplantation University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology University of Iowa Hospitals and Clinics Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.7.854"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.729831"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.09101.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05019.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09077.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1016\/j.jaad.2013.08.033","article-title":"Primary cutaneous t\u2010cell lymphoma (mycosis fungoides and sezary syndrome): part I. 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