{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:15:12Z","timestamp":1788995712564,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:00:00Z","timestamp":1533945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug reaction with eosinophilia and systemic symptoms (<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>) syndrome is a severe cutaneous drug reaction that can affect multiple internal organ systems. Cardiac involvement in<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>syndrome (CiDs) is uncommon but can be life\u2010threatening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence, risk factors, and mortality outcome of CiDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Forty\u2010one patients who were diagnosed with probable and definite<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>syndrome according to the Regi<jats:styled-content style=\"fixed-case\">SCAR<\/jats:styled-content>criteria were recruited. Cardiac involvement was evaluated by two independent cardiologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cardiac involvement was found in 8\/41 (19.5%) patients. Specifically, myocardial involvement was found in five patients, while three patients had pericardial involvement. The majority of culprit drugs were antibiotics followed by anti\u2010epileptic medications. The hemoglobin and albumin levels were significantly lower in the patients with CiDs when compared to the patients without CiDs (<jats:italic>P<\/jats:italic>\u2010value = 0.005 for both factors). The mortality rate at 30 and 90 days was significantly higher among CiDs patients, that is, 3\/8 (37.5%) versus 2\/28 (6.1%);<jats:italic>P<\/jats:italic>\u2010value = 0.02 and 4\/8 (50.0%) versus 2\/33 (6.1%);<jats:italic>P<\/jats:italic>\u2010value = 0.002 respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed the prevalence of CiDs was as high as 19.5% with high mortality rate. We suggest a thorough cardiac evaluation in all<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>patients with Regi<jats:styled-content style=\"fixed-case\">SCAR<\/jats:styled-content>score \u22654. The patients with CiDs had significantly lower hemoglobin and albumin levels, which might imply poor health condition, when compared to those without CiDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14174","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T01:23:46Z","timestamp":1534037026000},"page":"1187-1191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvement"],"prefix":"10.1111","volume":"57","author":[{"given":"Julphat","family":"Intarasupht","sequence":"first","affiliation":[{"name":"Phramongkutklao hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchisa","family":"Kanchanomai","sequence":"additional","affiliation":[{"name":"Phramongkutklao hospital Bangkok 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