{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:25:52Z","timestamp":1787635552793,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disorder of follicular occlusion, resulting in abscesses with tunnel formation and severe scarring. Our objectives were to identify the clinical patterns and the prevalence of metabolic syndrome (MetS) among our HS patients and to determine the role of ultrasonography in the clinical assessment of HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study carried out from September 2016 to August 2017 at three tertiary hospitals in Northern Peninsular Malaysia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 62 patients were recruited, 83.9% of whom were male. The mean age was 29.2 with the median age of onset at 18 years old. The median duration of delay in diagnosis was 3 years. A quarter of them had positive family history. Nearly three\u2010quarters were overweight and obese. About 12\/62 (19.4%) had MetS, and it was comparable to healthy controls (15\/62, 24.2%). HS patients had a significant higher risk of low\u2013high\u2010density lipoprotein (HDL) and obesity. Based on Hurley staging, 15\/62 (24.2%) were in stage I, 38\/62 (61.3%) and 9\/62 (14.5%) in stages II and III, respectively. However, sonographic scoring showed 50% had severe stage of disease, and 56.9% of the patients had subclinical lesions. There was only a fair agreement between ultrasonography and Hurley staging of disease severity (<jats:italic>k<\/jats:italic> = 0.25; <jats:italic>P<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a male preponderance among HS patients in Northern Peninsular Malaysia with early age of onset and more severe disease. Only one\u2010fifth had MetS, but they had significantly higher risks of obesity and low HDL. Ultrasonography examination was useful to detect subclinical lesions and providing a better understanding on disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14210","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T04:44:54Z","timestamp":1536122694000},"page":"1454-1463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The clinical, biochemical, and ultrasonographic characteristics of patients with hidradenitis suppurativa in Northern Peninsular Malaysia: a multicenter study"],"prefix":"10.1111","volume":"57","author":[{"given":"Chai Har","family":"Loo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Kuala Lumpur Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooi Chiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Pulau Pinang Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh Jong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Raja Permaisuri Bainun Ipoh Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yek Huan","family":"Khor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Pulau Pinang Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manimala T.","family":"Manikam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Sultanah Bahiyah Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyoi\u2010E","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Raja Permaisuri Bainun Ipoh Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Hong","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Pulau Pinang Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Hoe","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Raja Permaisuri Bainun Ipoh Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen Mey","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Radiology Hospital Sultanah Bahiyah Kedah Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Q. 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