{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T22:06:27Z","timestamp":1748469987636,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanomas arising from eyelid skin are exceptionally rare, accounting for &lt;1% of eyelid malignancies and all cutaneous melanomas. The aim of this study was to identify the histopathological features and clinical behaviors of the palpebral skin melanoma patients from a single tertiary institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Seventeen Caucasian patients diagnosed with eyelid cutaneous melanoma were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of patients was 59 years, and females were predominant (<jats:italic>n<\/jats:italic> = 11). The most frequent localization of the lesions was the lower eyelid (<jats:italic>n<\/jats:italic> = 8). Nodular (<jats:italic>n<\/jats:italic> = 4), lentigo maligna (<jats:italic>n<\/jats:italic> = 3), and the superficial spreading melanoma (<jats:italic>n<\/jats:italic> = 3) were the most common histopathological subtypes. Only three patients had <jats:italic>in situ<\/jats:italic> melanomas. Tumor infiltrating lymphocytes were present in most of the patients; however, only a few cases had lymphovascular invasion. Regional lymph node involvement was present in two patients, and distant metastasis was found in only one patient. Four patients (24%) had disease relapses during follow\u2010up, all of which were locoregional. The median relapse\u2010free survival (RFS) time and 5\u2010year RFS rate were 26.3 months and 60.4%, respectively. Two patients (12%) died. Median OS time was 32.1 months, and 5\u2010year OS rate was 84%. Being elderly (older than 60 years of age) (<jats:italic>P<\/jats:italic> = 0.05), lesion originating from canthus compared to eyelid (<jats:italic>P<\/jats:italic> = 0.03) and presence of recurrence in follow\u2010up (<jats:italic>P<\/jats:italic> = 0.04) have been found as poor prognostic indicators for OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Palpebral skin melanoma is associated with favorable clinical features, and it is correlated with better survival rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14212","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T05:46:46Z","timestamp":1535780806000},"page":"75-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-7116","authenticated-orcid":false,"given":"Faruk","family":"Tas","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Institute of Oncology University of Istanbul Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayhan","family":"Erturk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institute of Oncology University of Istanbul Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201701"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90161-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181961861"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2010.00475.x"},{"key":"e_1_2_5_6_1","first-page":"442","article-title":"Clinicopathologic features and prognostic factors of malignant eye lid tumors","volume":"6","author":"Wang CJ","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.151881"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/453091"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13902"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2011.07.001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200007000-00002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)00962-4"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.043"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2013.04.032"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T11:28:14Z","timestamp":1694777294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/ijd.14212"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14212","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"type":"print","value":"0011-9059"},{"type":"electronic","value":"1365-4632"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"assertion":[{"value":"2017-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}