{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:14:52Z","timestamp":1789881292254,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T00:00:00Z","timestamp":1536451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a distressing chronic skin disease. Its exact pathogenesis is still unclear, as many factors interplay in its occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study is to estimate elafin levels in the serum of both cases and controls and to correlate the levels with psoriasis severity and other markers of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Twenty\u2010six psoriatic cases along with 26 healthy controls were assigned in this case\u2010control study. Psoriasis severity was determined by Psoriasis Area and Severity Index score. Elafin levels were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> in serum of both cases and controls. C\u2010reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Elafin levels show highly statistical significance difference (<jats:italic>P<\/jats:italic> &lt; 0.001) between cases and controls. There is a statistical significant correlation between elafin levels and both psoriasis severity and inflammation markers as <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elafin represents a mirror for psoriasis severity and inflammatory state.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14217","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T05:34:33Z","timestamp":1536557673000},"page":"205-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Serum elafin as a potential inflammatory marker in psoriasis"],"prefix":"10.1111","volume":"58","author":[{"given":"Ibrahim","family":"Elgharib","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-6908","authenticated-orcid":false,"given":"Shrook A.","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa H.","family":"Elsaid","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M.","family":"Sharaf","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Faculty of Medicine Zagazig University Zagazig 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