{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:15:52Z","timestamp":1762542952701,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007771","name":"\u015al\u0105ski Uniwersytet Medyczny","doi-asserted-by":"publisher","award":["KNW\u20101\u2010029\/N\/6\/O"],"award-info":[{"award-number":["KNW\u20101\u2010029\/N\/6\/O"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis course involves increased secretion of pro\u2010inflammatory cytokines, among others, a beta transforming growth factor (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2s) and its receptors. Cyclosporine A (CsA), an immunosuppressive medicine with the molecular mechanism of operation connected with the properties of cell cycle suppression, is often used in the treatment of severe forms of psoriasis. The efficacy of therapy is assessed based on the disease clinical progression indexes \u2013 Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>), body surface area (<jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>), and Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>). The aim of the study was the evaluation of the efficacy of the CsA treatment of patients with psoriasis vulgaris, based on the clinical parameters and an assessment of the expression profiles of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2s and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u03b2Rs, depending on the concurrent diabetes and metabolic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The group under study composed of 32 patients (15 with the metabolic syndrome, seven with diabetes) treated with CsA for 84 days. The molecular analysis included extraction of <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, assessment of <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content><jats:italic>\u03b2<\/jats:italic>F1\u20103, <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content><jats:italic>\u03b2<\/jats:italic><jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> gene expression with the use of the <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>q<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> method. The clinical assessment of the effects of this pharmacotherapy involved evaluation of the parameters: <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BSA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DLQI<\/jats:styled-content> before therapy commencement, on the 42nd and 84th days of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant change in the transcription activity of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content><jats:italic>\u03b2<\/jats:italic>1 in patients with and without diabetes (<jats:italic>P<\/jats:italic> = 0.018) and patients with and without metabolic syndrome (<jats:italic>P<\/jats:italic> = 0.023) was shown that on the 84th day of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>b1 may be claimed as the supplementary molecular marker to evaluate the efficacy of CsA therapy. It seems that systemic diseases have an effect on the efficacy of the applied pharmacotherapy and the course of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14275","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:23:44Z","timestamp":1540268624000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and molecular evaluation of therapy with the use of cyclosporine A in patients with psoriasis vulgaris"],"prefix":"10.1111","volume":"58","author":[{"given":"Anna","family":"Michalska\u2010Ba\u0144kowska","sequence":"first","affiliation":[{"name":"Chair and Department of Dermatology School of Medicine in Katowice Medical University of Silesia Sosnowiec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-7592","authenticated-orcid":false,"given":"Dominika","family":"Wcis\u0142o\u2010Dziadecka","sequence":"additional","affiliation":[{"name":"Department of Skin Structural Studies Chair of Cosmetology, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec Medical University of Silesia Sosnowiec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beniamin","family":"Grabarek","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology School of Pharmacy with Division of Laboratory Medicine in Sosnowiec Medical University of Silesia Sosnowiec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Mazurek","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology School of Pharmacy with Division of Laboratory Medicine in Sosnowiec Medical University of Silesia Sosnowiec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Brzezi\u0144ska\u2010Wcis\u0142o","sequence":"additional","affiliation":[{"name":"Chair and Department of Dermatology School of Medicine in Katowice Medical University of Silesia Sosnowiec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Michalski","sequence":"additional","affiliation":[{"name":"School of Medicine in Katowice Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.ygeno.2013.11.001"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/j.jaad.2013.06.053"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Prevalence of metabolic syndrome in psoriasis patients and its relation to disease duration: a hospital based case\u2010control study","volume":"10","author":"Praveenkumar U","year":"2016","journal-title":"J Clin Diagn Res"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1590\/abd1806-4841.20164169"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1111\/1346-8138.13186"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/ijd.12811"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1001\/jamadermatol.2016.0670"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.4103\/1947-2714.168657"},{"key":"e_1_2_6_10_1","first-page":"455","article-title":"Leczenie \u0142uszczycy \u2013 rekomendacje ekspert\u00f3w Polskiego Towarzystwa Dermatologicznego. 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