{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:15:46Z","timestamp":1790111746835,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Noncultured epidermal cell suspension (<jats:styled-content style=\"fixed-case\">NCES<\/jats:styled-content>) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) has growth factors which may stimulate melanocyte migration and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of <jats:styled-content style=\"fixed-case\">NCES<\/jats:styled-content> suspended in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> with that of <jats:styled-content style=\"fixed-case\">NCES<\/jats:styled-content> suspended in phosphate buffered saline (<jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one patients of stable vitiligo with at least two lesions of comparable size were included. The two vitiligo patches were randomized to receive <jats:styled-content style=\"fixed-case\">NCES<\/jats:styled-content> suspended in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>. Postoperatively after 1 week, patients were given heliotherapy for 15 minutes daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 months follow\u2010up, mean repigmentation by area method in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> arm was 75.6 \u00b1 30% <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> and in non\u2010<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> arm was 65 \u00b1 34% <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.0036). Patient satisfaction by visual analogue scale at 6 months also showed better results in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> arm (<jats:italic>P<\/jats:italic> = 0.001). Assessment by three independent observers showed better repigmentation in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> side both at 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Suspending <jats:styled-content style=\"fixed-case\">NCES<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> can result in significantly greater mean repigmentation and patient satisfaction than suspending in <jats:styled-content style=\"fixed-case\">PBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14286","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T04:34:11Z","timestamp":1543811651000},"page":"472-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Use of platelet\u2010rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double\u2010blind randomized controlled trial"],"prefix":"10.1111","volume":"58","author":[{"given":"Nimitha","family":"Parambath","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; 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