{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:28:20Z","timestamp":1772029700778,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriatic patients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriatic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted on 30 moderate\u2010severe psoriasis vulgaris patients and 30 healthy controls. Body mass index, body fat percent, and <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> assessments were done. Serum endocan and tumor necrosis factor\u2010\u03b1 levels were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Carotid artery intima\u2010media thickness measurement by high\u2010resolution ultrasound was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psoriasis patients showed significantly higher serum tumor necrosis factor\u2010\u03b1 and endocan levels (P1 = 0.008, P2 = 0.003). Additionally, there was a statistically significant difference between mean carotid artery intima\u2010media thickness of both groups (<jats:italic>P<\/jats:italic> = 0.005). Serum endocan levels positively correlated with <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> score (<jats:italic>P<\/jats:italic> = 0.002), tumor necrosis factor\u2010\u03b1 levels (<jats:italic>P<\/jats:italic> &lt; 0.001), mean carotid artery intima\u2010media thickness (<jats:italic>P<\/jats:italic> = 0.001), and body mass index (<jats:italic>P<\/jats:italic> &lt; 0.001) in the patients group. Additionally, the age of onset of disease negatively correlated with serum endocan (<jats:italic>P<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum endocan is a promising marker of severity of psoriasis and associated atherosclerosis. Early onset psoriasis is associated with higher serum endocan levels. Body mass index is positively correlated with serum endocan levels. The positive correlation of endocan and tumor necrosis factor\u2010\u03b1 supports the regulatory effect of the cytokine on endocan production and suggests the role of endocan as an inflammatory marker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14290","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T04:30:48Z","timestamp":1543033848000},"page":"456-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Subclinical atherosclerosis in psoriatic disease: relation to endocan, <scp>TNF<\/scp>\u2010\u03b1, age of onset, and body fat"],"prefix":"10.1111","volume":"58","author":[{"given":"Abdelaal M.","family":"Elkamshoushi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-4366","authenticated-orcid":false,"given":"Salma S.","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr M.","family":"El Abd","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham Z.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A.","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Abd Elkawy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153038"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010058"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.94"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp567"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164169"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2014.0274"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"FangN JiangM FanY.Association between psoriasis and subclinical atherosclerosis. 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