{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:41:46Z","timestamp":1784886106143,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reports regarding squamous cell carcinoma of the nail unit (SCCnu) are rare in Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the features of SCCnu in the Asian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a retrospective review of patients diagnosed with <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>nu at our institution between 2012 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen cases were included. Thirteen patients were male (68.4%). The fingers were most frequently affected (73.7%). Mean delay to diagnosis was 62.4 months. Misdiagnosis rate was high (78.9%). Frequent clinical features were subungual tumor, subungual hyperkeratosis, nail dystrophy, ulcer, and nail loss. The majority of cases were invasive <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in 15 cases (78.9%), while <jats:styled-content style=\"fixed-case\">SCC <\/jats:styled-content><jats:italic>in situ<\/jats:italic> was found in four cases (21.1%). Local recurrence was detected in two cases (10.5%) following surgical resection. However, distant metastasis was not reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides data of 19 <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>nu cases in Asia. Clinical characteristics of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>nu in this study were similar to those of reports from Western countries. However, we found a higher frequency of more invasive cases and longer delay to diagnosis in our study; this advocates the need for greater attention on nail disorders among healthcare providers, particularly in Asia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14306","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T08:02:17Z","timestamp":1543305737000},"page":"428-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Squamous cell carcinoma of the nail unit: a retrospective review of 19 cases in Asia and comparative review of Western literature"],"prefix":"10.1111","volume":"58","author":[{"given":"Tae\u2010Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine Seoul National University College of Medicine Seoul 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