{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:54:38Z","timestamp":1694465678425},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFindTM<\/jats:sup><\/jats:styled-content> is a highly sensitive, noninvasive computer\u2010assisted system to aid in clinical diagnosis of melanoma.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 140 high\u2010risk patients were followed by one expert dermatologist. Biopsies were blindly and independently evaluated by two dermatopathologists and given histologic severity scores (HSS<\/jats:styled-content>, 0\u201312) based on the histologic features of melanoma\/dysplastic nevi and compared to pathologic diagnoses and MelaFindTM<\/jats:sup><\/jats:styled-content> scores.<\/jats:p><\/jats:sec>Results<\/jats:title>MelaFindTM<\/jats:sup><\/jats:styled-content> reduced the biopsy number of clinically ambiguous lesions (923 scanned to 253 biopsied, 73% reduction). Biopsied cases were usually benign (135\/253, 53.4%, HSS<\/jats:styled-content> = 2.8\u20133.2). Dysplastic nevi with varying degrees of atypia were observed next most commonly (80\/253, 31.6%, HSS<\/jats:styled-content> = 4.7\u20135.2 for mild dysplasia and 7\u20137.6 for moderate to severe dysplasia). Melanomas comprised 11\/253 (4.3%) of biopsies (HSS<\/jats:styled-content> = 9.3\u201310.7). Twenty\u2010four cases were given miscellaneous diagnoses not within the dysplastic nevus\u2013melanoma spectrum (9.5%, HSS<\/jats:styled-content> = 1.3). Dermal fibrosis was the most commonly identified worrisome histologic feature (177\/253, 70%), closely followed by other known atypical features. Nonthreatening histologic features in benign lesions with high MelaFindTM<\/jats:sup><\/jats:styled-content> disorganization scores were common. The HSS<\/jats:styled-content> differed significantly depending on pathologic diagnosis severity, while the MelaFindTM<\/jats:sup><\/jats:styled-content> score did not (benign = 2.2; mildly atypical = 4.8; moderately to severely atypical = 2.3; in\u2010situ or invasive melanoma = 3.1).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>MelaFindTM<\/jats:sup><\/jats:styled-content> unequivocally reduced the number of biopsies, but banal lesions had histologic attributes resulting in high\u2010risk MelaFindTM<\/jats:sup><\/jats:styled-content> scores, and MelaFindTM<\/jats:sup><\/jats:styled-content> does not correlate with degree of cytologic atypia. Knowledge of these limitations should increase bidirectional confidence when making clinicopathologic correlations in high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14336","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T06:50:43Z","timestamp":1544770243000},"page":"569-576","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histopathologic correlation of high\u2010risk MelaFindTM<\/sup> lesions: a 3\u2010year experience from a high\u2010risk pigmented lesion clinic"],"prefix":"10.1111","volume":"58","author":[{"given":"Vikas","family":"Shrivastava","sequence":"first","affiliation":[{"name":"Department of Dermatology Naval Medical Center Portsmouth Portsmouth VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Bailin","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Elliott","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Bacnik","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Gastman","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma","family":"Bergfeld","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"},{"name":"Pathology and Laboratory Medicine Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Billings","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"},{"name":"Pathology and Laboratory Medicine Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Piliang","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"},{"name":"Pathology and Laboratory Medicine Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"},{"name":"Pathology and Laboratory Medicine Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka","family":"Kovalyshyn","sequence":"additional","affiliation":[{"name":"US Path Labs Boca Raton FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Ko","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH USA"},{"name":"Pathology and Laboratory Medicine Institute Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.065"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1152"},{"key":"e_1_2_5_4_1","unstructured":"NeighmondP.Doctors question rise in skin cancer biopsies.NPR. 03 May 2007. Web. 25 June 2017."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1138"},{"key":"e_1_2_5_6_1","unstructured":"AllgeierCL YedidB.STRATA skin sciences Inc. Announces FDA approval of PMA supplemental for MelaFind\u00ae.Globe Newswire2016 March 10. Web."},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/ddg.12362","article-title":"To excise or not: impact of MelaFind on German dermatologists' decisions to biopsy atypical lesions","volume":"7","author":"Hauschild A","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.302"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.946"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.3405"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-37311-4"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T20:58:47Z","timestamp":1694379527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/ijd.14336"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14336","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]},"assertion":[{"value":"2018-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}