{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:21:00Z","timestamp":1773364860381,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus\u2010like keratosis (<jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>) is a frequent skin lesion usually biopsied to rule out basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>). Because of overlapping histopathological characteristics, <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> is frequently muddled with lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>), lichenoid actinic keratosis (<jats:styled-content style=\"fixed-case\">LAK<\/jats:styled-content>), and lupus erythematosus (<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical and histopathological characteristics of <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinicopathologic review was performed of all <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> cases (1366) signed in one calendar year in a busy academic practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> occurs mostly as a single lesion (97%) with the chest (41.4%) being the most common site. It is almost equally present in women and men (51.5%\u201348.5%). The most common clinical concern (65%) is basal cell carcinoma. Parakeratosis, red blood extravasation, and presence of dermal eosinophils and plasma cells, usually not seen in lichen planus, are helpful signs to suggest <jats:styled-content style=\"fixed-case\">LPLK<\/jats:styled-content> but are seen only in a minority of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicopathologic correlation is necessary to diagnose lichen planus\u2010like keratosis, as the most consistent feature is a clinical history of a lesion\/neoplastic process rather than an inflammatory process. There are histopathologic features that can help distinguish lichen planus\u2010like keratosis from lichen planus; however, these features are nonspecific and lacking in almost half of the cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14358","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T04:03:13Z","timestamp":1545192193000},"page":"830-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lichen planus\u2010like keratosis: clinicopathological evaluation of 1366 cases"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-4922","authenticated-orcid":false,"given":"Vladimir","family":"Vincek","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine University of Florida Gainesville FL 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