{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:25:06Z","timestamp":1750098306762,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T00:00:00Z","timestamp":1546128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2017\u2010474"],"award-info":[{"award-number":["2017\u2010474"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic value of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 expression in cutaneous extranodal natural killer\/T\u2010cell lymphoma is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicopathological features, survival outcomes, and prognostic implications of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 were retrospectively analyzed in 55 patients with cutaneous extranodal natural killer\/T\u2010cell lymphoma. We classified patients into (i) primary cutaneous extranodal natural killer\/T\u2010cell lymphoma and (ii) cutaneous extranodal natural killer\/T\u2010cell lymphoma secondary to nasal disease depending on the primary tumor site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ cutaneous extranodal natural killer\/T\u2010cell lymphoma was more common in patients with cutaneous extranodal natural killer\/T\u2010cell lymphoma secondary to nasal disease than in those with primary cutaneous disease. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ cases were more likely to present nodular lesions or cellulitis\u2010like swelling than <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30\u2212 cases. Histologically, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ cutaneous extranodal natural killer\/T\u2010cell lymphoma predominantly comprised large tumor cells compared with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30\u2212 cases. However, the clinical morphology and tumor cell size were not associated with survival outcomes. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 expression was associated with better survival outcomes in patients with cutaneous extranodal natural killer\/T\u2010cell lymphoma secondary to nasal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30+ cutaneous extranodal natural killer\/T\u2010cell lymphoma presented peculiar clinicopathological features and had more favorable disease course in patients with cutaneous dissemination from nasal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14362","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:37:52Z","timestamp":1546295872000},"page":"688-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CD30\u2010positive cutaneous extranodal natural killer\/T\u2010cell lymphoma: clinicopathological features and survival outcomes"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-464X","authenticated-orcid":false,"given":"Woo Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4166","authenticated-orcid":false,"given":"Ik Jun","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan 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