{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:07:34Z","timestamp":1791655654940,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With the rising incidence of melanoma <jats:italic>in\u00a0situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content>) or cutaneous melanoma, there is an increasing emphasis on the need to understand optimal treatment strategies. The current standard of surgical care is wide local excision (<jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>). Alternative surgical techniques have been proposed including Mohs micrographic surgery (<jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content>). We aimed to compare survival rates following <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> surgery for <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of the Surveillance, Epidemiology, and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) cancer registry. 24,515 cases of <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> were identified and compared with 4122 cases of <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> surgery for <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significantly higher proportion of elderly patients aged \u226575\u00a0years in the <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> group compared to <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> (23.3% vs. 15.3%). The proportion of females was higher for <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> (48.8% vs. 40%). Facial <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> tumors were significantly higher for <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content>, as were scalp\/neck tumors. After adjustment for confounding factors, there was no significant difference in cancer\u2010specific survival (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.928, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.596\u20131.446, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.74) and overall survival (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.006, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.896\u20131.129, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.924).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjusted analyses demonstrated no differences in overall survival or cancer\u2010specific survival between <jats:styled-content style=\"fixed-case\">MIS<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">MMS<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14374","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T09:50:38Z","timestamp":1546509038000},"page":"697-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mohs micrographic surgery versus wide local excision for melanoma <i>in situ<\/i>: analysis of a nationwide database"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-3555","authenticated-orcid":false,"given":"Kevin","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Liverpool, Sydney NSW Australia"},{"name":"South Western Sydney Clinical School University of New South Wales (UNSW) Liverpool, Sydney NSW 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