{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:22:54Z","timestamp":1765369374681},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Urticarial vasculitis (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) is a clinicopathologic entity in which skin lesions resemble urticaria clinically but last more than 24\u00a0hours and resolve with residual purpura. In this study, we evaluated distinguishing histological features of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> from common urticaria to differentiate between these two entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During 1 year, 55 urticaria and 245 <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> samples were assessed. The selection criteria for <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> included: (1) samples that the histological diagnosis was confirmed by two independent dermatopathologists, (2) the histological diagnosis of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> was inconsistent with the first clinical impression and lesion characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of our 245 <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> patients, 96% had endothelial swelling, 18% had red blood cell (RBC) extravasation, neutrophilic infiltration was seen in 46.7%, and perivascular, interstitial, and perineural eosinophilic infiltration in 198 (81.8%), 181 (74.2%), and 118 (48.1%), respectively. Among different histological findings, endothelial cell swelling as well as neutrophil around vessels and eosinophilic infiltrations were statistically different between two groups (<jats:italic>P<\/jats:italic>\u2010value\u00a0\u02c2\u00a00.001). Both urticaria and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> samples showed a predominantly lymphocytic infiltration more than 10 cells per high power field (HPF) (98.2% of urticaria, 98.8% of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>), and only two patients (0.8%) with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> had predominant neutrophilic infiltration (more than 10 cells\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have found that both urticaria and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> showed a predominantly lymphocytic infiltration along with <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> extravasation, endothelial cell swelling, and fibrin deposition in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>. Moreover, significant perineural, perivascular, and interstitial infiltration of eosinophil in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> lesions compared to urticaria was another point that indicates special contribution of these cells in <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14387","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T05:45:07Z","timestamp":1548740707000},"page":"825-829","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Eosinophilic infiltration: an under\u2010reported histological finding in urticarial vasculitis"],"prefix":"10.1111","volume":"58","author":[{"given":"Kambiz","family":"Kamyab","sequence":"first","affiliation":[{"name":"Department of Dermatopathology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Zahra","family":"Ghodsi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Disease Research Center Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Ghanadan","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafar","family":"Taghizadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Karimi","sequence":"additional","affiliation":[{"name":"student of medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Nasimi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Disease Research Center Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:23:2:201"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2972"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02891.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.687"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.962"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38956"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.12.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000786"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00146.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70069-R"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70139-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00295.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120908"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2000.00419.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.98"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.1.88"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000068"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.8.1140"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14387","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T23:33:45Z","timestamp":1694388825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/ijd.14387"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14387","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,28]]},"assertion":[{"value":"2018-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}