{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:18:48Z","timestamp":1768573128420,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007475","name":"Canadian Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007475","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) typically has a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> T\u2010cell phenotype. Rare cases of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup>, or <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> immunophenotypes have been described. Little is known about the impact of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> immunophenotypes on disease behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study to review all cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> from 2007 to 2017 from Sunnybrook Health Sciences Centre, Toronto, Canada. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> (Group 1) was compared to the three less common subtypes (Group 2) with respect to stage at diagnosis, progression, and transformation. Potential confounding factors (demographic, clinical, and laboratory parameters) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 160 patients with confirmed <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> were analyzed, including 126 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (79%), 26 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (16%), six <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (4%), and two <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (1%). Both groups were similar with respect to demographics and laboratory parameters at the time of diagnosis. There was no difference between patients with late stage disease (10% vs. 9%) for groups 1 and 2, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.901). There was no statistically significant difference either in 5\u2010year progression (27.7% vs. 23.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.283) or transformation (16.2% vs. 17.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.350) estimates. We did find that atypical immunophenotypes presented with different clinical morphologies and were less likely to require systemic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our large cohort study indicates that atypical <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> immunophenotypes do not seem to influence prognosis. Hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> was more frequent in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> group while folliculotropic <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> was exclusively seen in the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> group. We believe that cases of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> with aggressive behavior described in the literature represent misclassified primary cutaneous aggressive epidermotropic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T\u2010cell lymphoma. The small number of patients included in the study is a limiting factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14391","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T09:25:00Z","timestamp":1550136300000},"page":"933-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of the phenotype on mycosis fungoides prognosis, a retrospective cohort study of 160 patients"],"prefix":"10.1111","volume":"58","author":[{"given":"Alejandra","family":"Jaque","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine Sunnybrook Health Sciences Centre Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Mereniuk","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Sunnybrook Health Sciences Centre Toronto 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