{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:28:45Z","timestamp":1759991325274},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of chemotherapy\u2010related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical\u2010pathologic confirmation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although TEC is generally self\u2010limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14392","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T04:45:04Z","timestamp":1552020304000},"page":"856-860","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chemotherapy\u2010induced skin toxicity and capillary leak syndrome"],"prefix":"10.1111","volume":"58","author":[{"given":"Manrup K.","family":"Hunjan","sequence":"first","affiliation":[{"name":"Sandwell and West Birmingham Hospital Trusts Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaira","family":"Nowsheen","sequence":"additional","affiliation":[{"name":"Mayo Clinic Medical Scientist Training Program Mayo Clinic Alix School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro J.","family":"Ramos\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai West New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina G.","family":"Bridges","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia S.","family":"Lehman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic 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