{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:52:21Z","timestamp":1787496741167,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Stevens\u2010Johnson syndrome (\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      ) and toxic epidermal necrolysis (\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      ) are severe mucocutaneous disorders. To date, relatively few studies have looked at institutional approaches to treatment of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      , particularly with a focus on wound care.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective review was conducted on patients admitted to the Hennepin County Medical Center from 2007 to 2017 with a final diagnosis of\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      . Data were obtained for demographics, causative drug, hospital course, supportive care, medical management, complications, and disposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 48 were diagnosed with\n                      <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                      during the study period. A total of 41.7% (20\/48) were men, and the mean age was 49.2 years. Sulfa antibiotics and nonsulfa antibiotics were the most common causative drug categories, each accounting for a quarter of cases. Supportive measures included intravenous fluid resuscitation in 4.2% of cases, enteral nutrition in 75%, surgical debridement in 27.1%, and porcine xenograft in 16.7%. Wound care consisted of use of a cleanser in 95.8% of patients, topical antibiotic in 95.8%, topical steroid in 20.8%, topical antifungal in 14.6%, emollient in 83.3%, nonadherent dressing in 97.9%, silver impregnated dressing in 39.6%, nonsilver impregnated dressing in 79.2%, and general wrap in 93.8%. For medical treatment, 64.6% of patients received intravenous immunoglobulin (\n                      <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\n                      ), and 8.3% of patients received cyclosporine. Mortality rate was 12.5% overall, compared to an expected mortality rate of 25.2% as predicted by\n                      <jats:styled-content style=\"fixed-case\">SCORTEN<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients treated with our current regimen of care showed a mortality rate half of that predicted by\n                      <jats:styled-content style=\"fixed-case\">SCORTEN<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  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