{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:24Z","timestamp":1784775984512,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) and Stevens\u2010Johnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) are life\u2010threatening severe cutaneous drug reactions. There have been no Australian data published since 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether there is an association between prognosis and the type of systemic immune\u2010modulation treatment administered in a cohort of patients with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SJS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> overlap, and <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> at the New South Wales State <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> referral center \u2013 Concord Repatriation General Hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective, single center, cohort study of patients admitted with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> from January 1, 2006, to December 31, 2016, at Concord Repatriation General Hospital. Data on demographic information, the causative agent, treatment, and final survival outcome were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients included: 26 (62%) with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>, six (14%) with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> overlap, and 10 (24%) with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>. Overall mortality was 19% (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), and seven suffered <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. The average age of those who died was 60\u00a0years. Eighty\u2010one percent of patients were managed within the burn unit. Twenty\u2010nine patients (70%) received <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> within this group; 13 individuals also received systemic corticosteroids. Seven (17%) were managed with corticosteroid therapy alone. The incidence of death was 0% in the combined <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> and corticosteroid group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This series of 42 patients contributes valuable information to a serious condition with low global incidence and high mortality. There appears to be an apparent reduced mortality in the group of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients managed with combined <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> and corticosteroid. Larger cohorts are required to validate this relationship due to the risk of bias inherent to the retrospective study design and small sample size.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14426","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:12:06Z","timestamp":1553537526000},"page":"1141-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A 10\u2010year retrospective cohort study of the management of toxic epidermal necrolysis and Stevens\u2010Johnson syndrome in a New South Wales state referral hospital from 2006 to 2016"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6770-297X","authenticated-orcid":false,"given":"Linda","family":"Chan","sequence":"first","affiliation":[{"name":"Concord Repatriation General Hospital Sydney Local Health District Concord New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Cook","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital The Sydney University Concord Clinical School Concord Concord New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122135"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14530"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04184.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12118"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12702"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04166.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2013.03.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5668"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.01.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:30:02Z","timestamp":1694302202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/ijd.14426"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14426","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,25]]},"assertion":[{"value":"2018-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}