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The administration of these agents in special cases, such as in patients with HIV infection, previous malignancy, unclear vaccination status as well as children, can be challenging. This report is an updated systematic review of the use of biologics in the above\u2010mentioned groups. Articles derived from the databases PubMed, EMBASE, and SCOPUS, and published between 1989 and 2018, were analyzed for this study. The existing evidence is not in all cases sufficient in order to provide adequate insight on the management of these complex situations. The aim of this report is to present a summarized update on the knowledge of this special topic so far and to draw into attention the need to conduct more systematic studies so as to clarify the best therapeutic strategies for these special patient groups when it comes to the use of biologics.<\/jats:p>","DOI":"10.1111\/ijd.14436","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T05:48:57Z","timestamp":1553060937000},"page":"1008-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Challenges in the treatment of psoriasis with biologics: vaccination, history of malignancy, human immunodeficiency virus (HIV) infection, and pediatric psoriasis"],"prefix":"10.1111","volume":"58","author":[{"given":"Kerasia\u2010Maria","family":"Plachouri","sequence":"first","affiliation":[{"name":"Dermatology Department University of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Patras Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.11.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2018.06.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1054782"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15665"},{"key":"e_1_2_6_7_1","unstructured":"S3\u2010Leitlinie zur Therapie der Psoriasis vulgaris Update \u2013 2017. 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