{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:06:23Z","timestamp":1784775983990,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stevens\u2010Johnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) and toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) are rare and potentially life\u2010threatening mucocutaneous reactions. Given their rarity, limited cohort studies have been done. The aim of this study is to evaluate and compare the demographics, etiology, management, clinical and laboratory characteristics, complications, and outcome of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patients seen by the inpatient dermatology service at the University of Puerto Rico.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of 30 cases with identified diagnosis of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>, overlap <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN,<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> who were consulted to the Dermatology Department of the University of Puerto Rico from 2006 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 adult and six pediatric cases were reviewed. Females were predominant with a female to male ratio of 1.3\u00a0:\u00a01. The most frequent offending drugs identified were antibiotics (56.7%), anticonvulsants (23.3%), and nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) (16.7%) with the most frequent antibiotic identified being trimethoprim\/sulfamethoxazole (23.3%). Seventy percent of patients experienced at least one complication, most often of infectious etiology (80.1%). During hospital course, 73% received pharmacologic therapy (23% received <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> alone, 17% received steroids alone, and 33% both) versus 27% which received only supportive care. Mortality rate in this study was 13.8%. When comparing <jats:styled-content style=\"fixed-case\">SCORTEN<\/jats:styled-content> at day one of admission, deceased cases had a mean <jats:styled-content style=\"fixed-case\">SCORTEN<\/jats:styled-content> at day 1 of 4.0, while survivors had an average of 1.54 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibiotics followed by anticonvulsants were the most frequently offending drugs identified within this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.14493","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T11:52:46Z","timestamp":1559735566000},"page":"1293-1299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Stevens\u2010Johnson syndrome and toxic epidermal necrolysis: a retrospective descriptive study"],"prefix":"10.1111","volume":"58","author":[{"given":"Osward 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