{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:05:16Z","timestamp":1780589116828,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstracts<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thyroid hormones may play a key role in melasma; however, melasma link with thyroid disorders remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the serum levels of thyroid\u2010stimulating hormone (TSH), T4, T3, anti\u2010thyroid peroxidase (anti\u2010TPO), and antithyroglobulin between patients with melasma and control group using meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We screened 10 databanks and search engines, searched mesh and nonmesh terms. The identified evidences were reviewed and quality assessed using the Newcastle\u2010Ottawa Scale (NOS). The heterogeneity between the primary results was investigated using Cochrane and\n                      <jats:italic>I<\/jats:italic>\n                      \u2010square indices. Random effect model was applied to combine the standardized mean differences of thyroid function indicators between patients with and without melasma.\n                      <jats:italic>P<\/jats:italic>\n                      values meta\u2010analysis was used to investigate the association between anti\u2010TPO and melasma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included seven studies, 473 cases, and 379 controls that had been investigated. The total standardized mean differences (95% confidence intervals) of TSH, T3, T4, and antithyroglobulin antibody between cases and controls were estimated to be 0.33 (0.18, 0.47), \u22120.01 (\u22120.20, 0.19), \u22121.50 (\u22122.96, \u22120.04), and 0.62 (0.14, 1.11), respectively. The corresponding figures among women were 0.35 (0.17, 0.52), 0.10 (\u22120.17, 0.38), \u22122.75 (\u22126.30, 0.81), and 0.99 (0.14, 1.83), respectively.\n                      <jats:italic>P<\/jats:italic>\n                      value of meta\u2010analysis showed a significant relationship between anti\u2010TPO serum level and melasma (Fisher\u00a0=\u00a026.80,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum levels of TSH, anti\u2010TPO, and antithyroglobulin antibody were significantly higher in patients with melasma than those without melasma. Moreover, these differences were more severe among women with melasma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.14497","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T08:04:24Z","timestamp":1559289864000},"page":"1231-1238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Melasma and thyroid disorders: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"58","author":[{"given":"Motahhareh","family":"Kheradmand","sequence":"first","affiliation":[{"name":"Health Science Research Center Addiction Institute Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Afshari","sequence":"additional","affiliation":[{"name":"Department of Community Medicine School of Medicine Zabol University of Medical Sciences Zabol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Damiani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Case Western Reserve University Cleveland OH USA"},{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano Unit\u00e0 Operativa di Dermatologia IRCCS Fondazione Ca\u2019 Granda Ospedale Maggiore Policlinico Milano Italy"},{"name":"Young Dermatologists Italian Network (YDIN) GISED Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Abediankenari","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Mazandaran University of Medical Sciences Sari Iran"},{"name":"Immunogenetics Research Center School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-514X","authenticated-orcid":false,"given":"Mahmood","family":"Moosazadeh","sequence":"additional","affiliation":[{"name":"Health Science Research Center Addiction Institute Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e65"},{"key":"e_1_2_6_3_1","first-page":"578","article-title":"Chemical peels in melasma: a review with consensus recommendations by Indian pigmentary expert group","volume":"62","author":"Sarkar R","year":"2017","journal-title":"Indian J Dermatol"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Natural options for management of melasma, a review","author":"Nomakhosi M","year":"2018","journal-title":"J Cosmet Laser Ther"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001518"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_187_17"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0194-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13578"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.113951"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343905"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.28922\/qmj.2016.12.21.107-111","article-title":"The prevalence of thyroid disorders in patients with melasma","volume":"12","author":"Al\u2010Shamma YM","year":"2017","journal-title":"AL\u2010Qadisiyah Med J"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2015.54742"},{"key":"e_1_2_6_14_1","first-page":"154","article-title":"Asosiation between melasma and thyroid disorder","volume":"9","author":"Kiani AAM","year":"2006","journal-title":"Iran J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12138"},{"key":"e_1_2_6_16_1","first-page":"19","article-title":"The relationship between melasma and disturbances in the serum level of thyroid hormones and indices","volume":"2","author":"Talaee R","year":"2015","journal-title":"Med J"},{"key":"e_1_2_6_17_1","first-page":"51","article-title":"Association of melasma with thyroid autoimmunity: a case\u2010control study","volume":"13","author":"Yazdanfar A","year":"2010","journal-title":"Iran J Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-1-28"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.17027"},{"key":"e_1_2_6_20_1","unstructured":"MoosazadehM.Comparison of thyroid disorder between patients with melasma and control group: a systematic review and meta\u2010analysis: PROSPERO 2018. CRD42018099964. Available from:http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?ID=CRD42018099964."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9554.1000429"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2016\/392"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.14497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.14497","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.14497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T19:20:54Z","timestamp":1721330454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.14497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/ijd.14497"],"URL":"https:\/\/doi.org\/10.1111\/ijd.14497","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735894211.793566098","asserted-by":"object"}]},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,31]]},"assertion":[{"value":"2019-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}