{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:33:09Z","timestamp":1793215989671,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hidradenitis suppurativa (\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      ) is a debilitating and distressing chronic systemic inflammatory skin disease. There have been several prior observational studies which reported a possibility link between\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and metabolic syndrome, however the current evidence is not definitive. It is unclear in\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      whether this possible relationship is independent or driven by underlying risk factors and comorbidities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine whether\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      is independently associated with metabolic syndrome via adjusted meta\u2010analysis of case\u2010control studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta\u2010analysis was performed according to\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      guidelines. Electronic searches were performed using six electronic databases (Ovid Medline, PubMed, CCTR, CDSR, ACP Journal Club, and DARE) from their inception until September 2018. Data were extracted and analyzed according to predefined clinical endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified six case\u2010control studies included for meta\u2010analysis. Based on unadjusted analysis, we found a significant association between adult cases of\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and metabolic syndrome (OR 1.95, 95% CI 1.31\u20132.89,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Adjusted meta\u2010analysis, after adjustment for age, sex, other cardiovascular risk factors, and comorbidities, found a significant association (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      2.19, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.70\u20132.81,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a032%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Studies reviewed were observational by design which are susceptible to bias, and there was\u00a0lack of randomization. The quality of the current systematic review is also limited by the quality of available evidence which was predominantly observational in nature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This pooled analysis of existing case\u2010control studies supports an association between\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and metabolic syndrome. Clinicians treating patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      should be aware of this potential association.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.14500","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T03:57:22Z","timestamp":1559275042000},"page":"1112-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hidradenitis suppurativa and metabolic syndrome \u2013 systematic review and adjusted meta\u2010analysis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-3555","authenticated-orcid":false,"given":"Kevin","family":"Phan","sequence":"first","affiliation":[{"name":"Department of Dermatology Liverpool Hospital Sydney Australia"},{"name":"Faculty of Medicine University of New South Wales Sydney 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